TFBS = ADD

CisView: Mouse (mm6, March2005)

Transcription factor binding site ADD_AIRE

Source: Kumar PG, Laloraya M, Wang CY, Ruan QG, Davoodi-Semiromi A, Kao KJ, She JX. 2001. The autoimmune regulator (AIRE) is a DNA-binding protein. J Biol Chem. 276:41357-64.
TF group: AIRE TFBS class: HOX = Homeobox Code: 3.1.1
Pattern = TTGGTTATATTGG (core elements are bold) Class: AIRE Allowed mismatch: 0.148
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Position weight matrix:

position A C G T
1 8 10 9 31
2 8 5 5 42
3 0 0 60 0
4 0 0 61 0
5 13 3 1 44
6 12 4 1 44
7 34 6 7 8
8 11 4 7 29
9 25 6 8 11
10 13 4 3 30
11 10 7 2 30
12 0 1 47 1
13 1 1 47 0

Genes (trans-elements):

U-cluster Symbol Annotation
U031966 Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

GO terms:
GO:0045182 translation regulator activity
GO:0006959 humoral immune response

Protein domains:
IPR001965 Zn-finger-like, PHD finger
IPR000770 SAND
IPR011011 FYVE/PHD zinc finger
IPR004865 Sp100
IPR008087 Autoimmune regulator, AIRE
IPR010919 SAND-like

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

position	A	C	G	T
1	8	10	9	31
2	8	5	5	42
3	0	0	60	0
4	0	0	61	0
5	13	3	1	44
6	12	4	1	44
7	34	6	7	8
8	11	4	7	29
9	25	6	8	11
10	13	4	3	30
11	10	7	2	30
12	0	1	47	1
13	1	1	47	0

U-cluster	Symbol	Annotation
U031966	Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

Legend