CisView: Mouse (mm6, March2005)
Transcription factor binding site ADD_SMAD

Source: Kusanagi K, Inoue H, Ishidou Y, Mishima HK, Kawabata M, Miyazono K. 2000. Characterization of a bone morphogenetic protein-responsive Smad-binding element. Mol Biol Cell. 11:555-65.
TF group: SMAD       TFBS class: SMAD       Code: 4.12.1
Pattern = GCCGCCGC     Class: SMAD     Allowed mismatch: 0.2     Palindrome
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Genes (trans-elements):
U-clusterSymbol
Annotation
U029992Smad1MAD homolog 1 (Drosophila)
U030990Smad3MAD homolog 3 (Drosophila)
U038549Smad4MAD homolog 4 (Drosophila)
U141140Smad2MAD homolog 2 (Drosophila)

GO terms:
GO:0007182 common-partner SMAD protein phosphorylation
GO:0009887 organogenesis
GO:0007183 SMAD protein heteromerization
GO:0016563 transcriptional activator activity
GO:0051098 regulation of binding
GO:0008134 transcription factor binding
GO:0003690 double-stranded DNA binding
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0009952 anterior/posterior pattern formation
GO:0001707 mesoderm formation
GO:0048340 paraxial mesoderm morphogenesis
GO:0016202 regulation of myogenesis
GO:0010003 gastrulation (sensu Mammalia)
GO:0045165 cell fate commitment
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0045941 positive regulation of transcription
GO:0007184 SMAD protein nuclear translocation
GO:0005886 plasma membrane
GO:0030509 BMP signaling pathway
GO:0007276 gametogenesis
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0042592 homeostasis
GO:0007242 intracellular signaling cascade
GO:0050678 regulation of epithelial cell proliferation
GO:0000165 MAPKKK cascade

Protein domains:
IPR008984 SMAD/FHA
IPR003619 Dwarfin protein, A
IPR001132 Dwarfin protein
IPR001093 IMP dehydrogenase/GMP reductase

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

Legend