CisView: Mouse (mm6, March2005)
Transcription factor binding site MIT_002MYC

Source: Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M. 2005. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature 434(7031):338-345.
TF group: MYC       TFBS class: bHLH = Helix-loop-helix       Code: 1.3
Pattern = CACGTG     Class: MYC     Allowed mismatch: 0.2     Palindrome
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Genes (trans-elements):
U-clusterSymbol
Annotation
U034094MaxMax protein
U016291Mycmyelocytomatosis oncogene

GO terms:
GO:0006919 caspase activation
GO:0042981 regulation of apoptosis
GO:0000074 regulation of cell cycle
GO:0006309 DNA fragmentation during apoptosis
GO:0008634 negative regulation of survival gene product activity
GO:0009314 response to radiation
GO:0001836 release of cytochrome c from mitochondria
GO:0042127 regulation of cell proliferation
GO:0005819 spindle
GO:0008633 activation of pro-apoptotic gene products
GO:0008629 induction of apoptosis by intracellular signals

Protein domains:
IPR001092 Basic helix-loop-helix dimerisation region bHLH
IPR002418 Transcription regulator Myc
IPR011598 Helix-loop-helix DNA-binding
IPR003327 Leucine zipper, Myc

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

Legend