CisView: Mouse (mm6, March2005)
Transcription factor binding site MIT_016ETS

Source: Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M. 2005. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature 434(7031):338-345.
TF group: ETS       TFBS class: MYB/ETS = Tryptophan clusters       Code: 3.5.2.0
Pattern = RYTTCCTG     Class: ETS     Allowed mismatch: 0.2
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Genes (trans-elements):
U-clusterSymbol
Annotation
U015885Elf1E74-like factor 1
U221053Elk1ELK1, member of ETS oncogene family
U025990Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 2
U037336Ergavian erythroblastosis virus E-26 (v-ets) oncogene related
U010230Ets1E26 avian leukemia oncogene 1, 5' domain
U030653Fli1Friend leukemia integration 1
U043544GabpaGA repeat binding protein, alpha
U040971Gabpb1GA repeat binding protein, beta 1
U024357Gabpb2GA repeat binding protein, beta 2
U042920Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
U033457Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)
U029840Sap30Mus musculus sin3 associated polypeptide (Sap30), mRNA
U032106SpicSpi-C transcription factor (Spi-1/PU.1 related)
U037751Tcf19transcription factor 19
U042770Etv6ets variant gene 6 (TEL oncogene)
U010230Ets1E26 avian leukemia oncogene 1, 5' domain
U017415Ets2E26 avian leukemia oncogene 2, 3' domain
U007419Tnfrsf1atumor necrosis factor receptor superfamily, member 1a

GO terms:
GO:0000074 regulation of cell cycle
GO:0008015 circulation
GO:0007165 signal transduction
GO:0009887 organogenesis
GO:0005886 plasma membrane
GO:0005887 integral to plasma membrane
GO:0006693 prostaglandin metabolism
GO:0048265 response to pain
GO:0005261 cation channel activity
GO:0000160 two-component signal transduction system (phosphorelay)
GO:0008016 regulation of heart contraction rate
GO:0001817 regulation of cytokine production
GO:0004872 receptor activity
GO:0005251 delayed rectifier potassium channel activity
GO:0042803 protein homodimerization activity
GO:0006952 defense response
GO:0000155 two-component sensor molecule activity
GO:0006936 muscle contraction
GO:0005031 tumor necrosis factor receptor activity
GO:0015293 symporter activity
GO:0005216 ion channel activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0006811 ion transport
GO:0007242 intracellular signaling cascade
GO:0030154 cell differentiation
GO:0005386 carrier activity
GO:0006813 potassium ion transport
GO:0008045 motor axon guidance
GO:0005244 voltage-gated ion channel activity
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0005164 tumor necrosis factor receptor binding
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0005635 nuclear membrane
GO:0005624 membrane fraction
GO:0007166 cell surface receptor linked signal transduction
GO:0008076 voltage-gated potassium channel complex
GO:0007515 lymph gland development
GO:0006954 inflammatory response
GO:0006915 apoptosis
GO:0006812 cation transport
GO:0005267 potassium channel activity
GO:0016563 transcriptional activator activity
GO:0006836 neurotransmitter transport
GO:0008219 cell death
GO:0005249 voltage-gated potassium channel activity
GO:0016580 Sin3 complex

Protein domains:
IPR000418 Ets
IPR002341 HSF/ETS, DNA-binding
IPR003118 Sterile alpha motif/pointed
IPR010993 Sterile alpha motif homology
IPR001093 IMP dehydrogenase/GMP reductase
IPR002110 Ankyrin
IPR006209 EGF-like
IPR005821 Ion transport protein
IPR001368 TNFR/CD27/30/40/95 cysteine-rich region
IPR001610 PAC motif
IPR000253 Forkhead-associated
IPR000014 PAS
IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
IPR008984 SMAD/FHA
IPR011029 DEATH-like
IPR005820 Cation channel, non-ligand gated
IPR000175 Sodium:neurotransmitter symporter
IPR000488 Death
IPR000595 Cyclic nucleotide-binding
IPR003938 EAG/ELK/ERG potassium channel
IPR003967 Erg channel
IPR000700 PAS-associated, C-terminal
IPR002035 von Willebrand factor, type A
IPR001622 K+ channel, pore region
IPR002435 Noradrenaline neurotransmitter transporter

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

Legend