CisView: Mouse (mm6, March2005)
Transcription factor binding site TF_MYC

Database: TRANSFAC
Source: Matys V, Fricke E, Geffers R, Gößling E, Haubrock M, et al. 2003. TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res., 31, 374-378.
TF group: MYC       TFBS class: bHLH = Helix-loop-helix       Code: 1.3
Pattern = YCACGTGD (core elements are bold)     Class: MYC     Allowed mismatch: 0.121     Palindrome
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Matrixes from TRANSFAC:
Matrix
Pattern
Orientation
V$NMYC_01 ____NNCCACGTGN
+
V$MYCMAX_01 ___NNACCACGTGG
+
V$MAX_01 ___NNANCACGTGN
+
V$USF_01 ___NNRYCACGTGR
+
V$USF_02 ___NNRNCACGTGN
+
V$MYCMAX_02 ____NANCACGTGN
+
V$USF_Q6 _____GYCACGTGN
+
V$USF_C ______NCACGTGN
+
V$MYCMAX_03 NNNNNNNCACGTGNNNNNNN
+

Genes (trans-elements):
U-clusterSymbol
Annotation
U016291Mycmyelocytomatosis oncogene
U034094MaxMax protein

GO terms:
GO:0006919 caspase activation
GO:0042981 regulation of apoptosis
GO:0009314 response to radiation
GO:0042127 regulation of cell proliferation
GO:0000074 regulation of cell cycle
GO:0006309 DNA fragmentation during apoptosis
GO:0008634 negative regulation of survival gene product activity
GO:0001836 release of cytochrome c from mitochondria
GO:0005819 spindle
GO:0008633 activation of pro-apoptotic gene products
GO:0008629 induction of apoptosis by intracellular signals

Protein domains:
IPR001092 Basic helix-loop-helix dimerisation region bHLH
IPR002418 Transcription regulator Myc
IPR011598 Helix-loop-helix DNA-binding
IPR003327 Leucine zipper, Myc

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

Legend