CisView: Mouse (mm6, March2005)
Transcription factor binding site TF_NFKB

Database: TRANSFAC
Source: Matys V, Fricke E, Geffers R, Gößling E, Haubrock M, et al. 2003. TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res., 31, 374-378.
TF group: NFKB       TFBS class: RHR = Rel homology region       Code: 4.1.1.0
Pattern = GGGRMTTYCC (core elements are bold)     Class: NFKB     Allowed mismatch: 0.171     Palindrome
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Matrixes from TRANSFAC:
Matrix
Pattern
Orientation
V$NFKAPPAB50_01 __GGGGATYCCC
+
V$NFKAPPAB65_01 __GGGRATTTCC
+
V$CREL_01 __SGGRNTTTCC
+
V$NFKAPPAB_01 __GGGAMTTYCC
+
V$NFKB_Q6 NGGGGAMTTTCCNN
+
V$NFKB_C _NGGGACTTTCC
+

Genes (trans-elements):
U-clusterSymbol
Annotation
U024684Nfkb1nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
U019521Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100
U032577Relreticuloendotheliosis oncogene
U029454Deaf1deformed epidermal autoregulatory factor 1 (Drosophila)

GO terms:
GO:0007165 signal transduction
GO:0007515 lymph gland development
GO:0045084 positive regulation of interleukin-12 biosynthesis
GO:0000074 regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-dependent
GO:0045083 negative regulation of interleukin-12 biosynthesis
GO:0016566 specific transcriptional repressor activity
GO:0003713 transcription coactivator activity
GO:0006915 apoptosis

Protein domains:
IPR000451 NF-kappa-B/Rel/dorsal
IPR008967 p53-like transcription factor, DNA-binding
IPR002909 Cell surface receptor IPT/TIG
IPR011539 Rel homology
IPR001093 IMP dehydrogenase/GMP reductase
IPR000488 Death
IPR002110 Ankyrin
IPR010919 SAND-like
IPR002893 Zn-finger, MYND type
IPR011029 DEATH-like
IPR000770 SAND

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

Legend