CisView: Mouse (mm6, March2005)
Transcription factor binding site TF_STAT

Database: TRANSFAC
Source: Matys V, Fricke E, Geffers R, Gößling E, Haubrock M, et al. 2003. TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res., 31, 374-378.
TF group: STAT       TFBS class: STAT = STAT       Code: 4.2.1.0
Pattern = WTTCCNGGAA (core elements are bold)     Class: STAT     Allowed mismatch: 0.158     Palindrome
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Matrixes from TRANSFAC:
Matrix
Pattern
Orientation
V$STAT_01 ______TTCCCGKAA
+
V$STAT1_01 NNNSANTTCCGGGAANTGNSN
+
V$STAT3_01 NGNNATTTCCSGGAARTGNNN
+
V$STAT5A_01 ___NAWTTCYNGGAA
+
V$STAT5B_01 ___NAWTTCYNGGAA
+
V$STAT5A_02 ______TTCCNRGAANNNNNNTTC
+
V$STAT1_03 ___NNTTTCCN
+
V$STAT3_02 ___NNNTTCCN
+
V$STAT4_01 ___SNWTTCNN
+
V$STAT5A_04 ___NNNTTCYN
+
V$STAT6_02 ___NNYTTCCY
+

Genes (trans-elements):
U-clusterSymbol
Annotation
U000262Stat4signal transducer and activator of transcription 4
U000263Stat1signal transducer and activator of transcription 1
U012152Stat6signal transducer and activator of transcription 6
U012176Stat2signal transducer and activator of transcription 2
U013347Stat5asignal transducer and activator of transcription 5A
U033437Stat5bsignal transducer and activator of transcription 5B
U033438Stat3signal transducer and activator of transcription 3

GO terms:
GO:0007242 intracellular signaling cascade
GO:0007165 signal transduction
GO:0019221 cytokine and chemokine mediated signaling pathway
GO:0007259 JAK-STAT cascade
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045086 positive regulation of interleukin-2 biosynthesis
GO:0019915 lipid storage
GO:0030155 regulation of cell adhesion
GO:0046544 development of secondary male sexual characteristics
GO:0030856 regulation of epithelial cell differentiation
GO:0001553 luteinization
GO:0046543 development of secondary female sexual characteristics
GO:0045931 positive regulation of mitotic cell cycle
GO:0042104 positive regulation of activated T cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0043066 negative regulation of apoptosis
GO:0043029 T cell homeostasis
GO:0050729 positive regulation of inflammatory response
GO:0045885 positive regulation of survival gene product activity
GO:0007595 lactation
GO:0040018 positive regulation of body size
GO:0001779 natural killer cell differentiation
GO:0008283 cell proliferation
GO:0006953 acute-phase response
GO:0042127 regulation of cell proliferation
GO:0005507 copper ion binding
GO:0006118 electron transport
GO:0001754 eye photoreceptor cell differentiation
GO:0005489 electron transporter activity
GO:0030879 mammary gland development
GO:0005886 plasma membrane
GO:0046983 protein dimerization activity
GO:0016563 transcriptional activator activity

Protein domains:
IPR000980 SH2 motif
IPR008967 p53-like transcription factor, DNA-binding
IPR001217 STAT protein
IPR001093 IMP dehydrogenase/GMP reductase
IPR000859 CUB
IPR000923 Blue (type 1) copper domain

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

Legend