Gene Ontology terms for targets of TF

CisView Mouse (mm6, March 2005)

Main Gene Ontology terms for targets of TF_AP2

No.	GO annotation	Total genes with GO	Location	Max no. of genes with TF_AP2	TF_AP2 alone	In pair with
1	GO:0003676 nucleic acid binding	2302	at_TSS,after_TSS	188		TF_AP2, TF_MAZR,
2	GO:0019222 regulation of metabolism	1541	before_TSS,after_TSS	185		TF_MAZR,
3	GO:0006350 transcription	1461	at_TSS,before_TSS,after_TSS	180		many
4	GO:0031323 regulation of cellular metabolism	1510	before_TSS,after_TSS	180		MIT_024MAZ, TF_MAZR, MIT_006SP1,
5	GO:0003677 DNA binding	1509	at_TSS,before_TSS,after_TSS	179		many
6	GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	1420	at_TSS,before_TSS,after_TSS	176		many
7	GO:0045449 regulation of transcription	1410	at_TSS,before_TSS,after_TSS	176		many
8	GO:0006351 transcription, DNA-dependent	1383	before_TSS,after_TSS	174		TF_AP2, TF_MAZR, MIT_006SP1,
9	GO:0006355 regulation of transcription, DNA-dependent	1362	before_TSS,after_TSS	171		TF_AP2, TF_MAZR, MIT_006SP1,
10	GO:0050791 regulation of physiological process	2046	after_TSS	167		MIT_024MAZ, TF_MAZR,
11	GO:0051244 regulation of cellular physiological process	1986	after_TSS	166		TF_MAZR,
12	GO:0030528 transcription regulator activity	941	before_TSS,after_TSS	166	yes	many
13	GO:0006512 ubiquitin cycle	390	at_TSS,after_TSS	145	yes	many
14	GO:0003700 transcription factor activity	719	before_TSS,after_TSS	128	yes	many
15	GO:0016773 phosphotransferase activity, alcohol group as acceptor	553	at_TSS,after_TSS	105	yes	TF_SP1, TF_AP2, TF_AP2A,
16	GO:0016879 ligase activity, forming carbon-nitrogen bonds	302	after_TSS	97		TF_SP1,
17	GO:0009790 embryonic development	170	at_TSS,before_TSS,after_TSS	96	yes	many
18	GO:0016310 phosphorylation	549	after_TSS	94		TF_SP1,
19	GO:0016881 acid-amino acid ligase activity	273	after_TSS	93	yes	TF_AP2, TF_SP1,
20	GO:0004713 protein-tyrosine kinase activity	381	at_TSS,before_TSS,after_TSS	92	yes	many
21	GO:0007275 development	1378	before_TSS	91		TF_AP2A,
22	GO:0004842 ubiquitin-protein ligase activity	263	after_TSS	90		many
23	GO:0008104 protein localization	508	after_TSS	88		MIT_024MAZ,
24	GO:0006468 protein amino acid phosphorylation	476	before_TSS,after_TSS	87	yes	TF_AP2, TF_SP1, MIT_006SP1,
25	GO:0015031 protein transport	476	after_TSS	86		MIT_024MAZ,
26	GO:0046907 intracellular transport	478	after_TSS	86		MIT_024MAZ,
27	GO:0004672 protein kinase activity	466	after_TSS	86	yes	TF_AP2, TF_SP1,
28	GO:0006796 phosphate metabolism	654	before_TSS	84		MIT_006SP1,
29	GO:0006793 phosphorus metabolism	654	before_TSS	84		MIT_006SP1,
30	GO:0004674 protein serine/threonine kinase activity	418	after_TSS	83		TF_AP2, TF_SP1,
31	GO:0046914 transition metal ion binding	1070	after_TSS	83		TF_SP1, TF_AP2A,
32	GO:0016301 kinase activity	684	at_TSS,after_TSS	78		TF_AP2, TF_AP2A, MIT_006SP1,
33	GO:0006886 intracellular protein transport	350	after_TSS	75		MIT_024MAZ,
34	GO:0008270 zinc ion binding	901	before_TSS,after_TSS	73		many
35	GO:0048519 negative regulation of biological process	408	before_TSS,after_TSS	70	yes	MIT_024MAZ,
36	GO:0007389 pattern specification	128	at_TSS,before_TSS,after_TSS	69	yes	TF_MAZR,
37	GO:0007399 nervous system development	301	at_TSS,after_TSS	69	yes	many
38	GO:0007049 cell cycle	443	at_TSS,before_TSS	68		TF_SP1, TF_EGR1, MIT_006SP1,
39	GO:0043412 biopolymer modification	1267	at_TSS	67		MIT_030,
40	GO:0048523 negative regulation of cellular process	375	before_TSS,after_TSS	66	yes
41	GO:0048468 cell development	162	after_TSS	66	yes	MIT_006SP1,
42	GO:0006464 protein modification	1178	at_TSS	65		MIT_030,
43	GO:0007167 enzyme linked receptor protein signaling pathway	157	at_TSS,after_TSS	60	yes	MIT_045,
44	GO:0030554 adenyl nucleotide binding	1036	at_TSS	57		TF_NFKB,
45	GO:0030182 neuron differentiation	137	at_TSS,after_TSS	57	yes	TF_SP1, MIT_006SP1,
46	GO:0005524 ATP binding	1011	at_TSS	56		TF_NFKB,
47	GO:0009653 morphogenesis	811	at_TSS	55	yes	MIT_024MAZ,
48	GO:0008092 cytoskeletal protein binding	219	at_TSS	54	yes	TF_SP1, TF_OLF1, MIT_006SP1,
49	GO:0030154 cell differentiation	538	after_TSS	53		MIT_006SP1,
50	GO:0009887 organ morphogenesis	674	at_TSS,before_TSS	52	yes	TF_AP2A,
51	GO:0004721 phosphoprotein phosphatase activity	118	at_TSS,after_TSS	52	yes	MIT_006SP1,
52	GO:0030001 metal ion transport	288	before_TSS	50	yes	MIT_035MYOD,
53	GO:0009792 embryonic development (sensu Metazoa)	85	at_TSS,before_TSS	48	yes
54	GO:0016311 dephosphorylation	105	at_TSS,after_TSS	46	yes	TF_SP1, MIT_006SP1,
55	GO:0016071 mRNA metabolism	202	after_TSS	45		many
56	GO:0048666 neuron development	108	after_TSS	45	yes	MIT_006SP1,
57	GO:0051243 negative regulation of cellular physiological process	330	after_TSS	44	yes
58	GO:0000074 regulation of progression through cell cycle	246	before_TSS	43		MIT_024MAZ, TF_SP1, MIT_006SP1,
59	GO:0007417 central nervous system development	76	at_TSS,before_TSS,after_TSS	43	yes	MIT_140, TF_MAZR, TF_PAX4,
60	GO:0016055 Wnt receptor signaling pathway	81	at_TSS,before_TSS,after_TSS	43	yes	TF_SP1, MIT_006SP1,
61	GO:0006470 protein amino acid dephosphorylation	99	at_TSS,after_TSS	43	yes	TF_SP1, MIT_006SP1,
62	GO:0006397 mRNA processing	189	before_TSS,after_TSS	41		many
63	GO:0031175 neurite morphogenesis	96	after_TSS	39	yes	MIT_006SP1,
64	GO:0048667 neuron morphogensis during differentiation	96	after_TSS	39	yes	MIT_006SP1,
65	GO:0006605 protein targeting	141	after_TSS	38		MIT_024MAZ,
66	GO:0051276 chromosome organization and biogenesis	220	before_TSS,after_TSS	37	yes	many
67	GO:0007610 behavior	229	before_TSS	37	yes
68	GO:0019941 modification-dependent protein catabolism	94	after_TSS	36	yes
69	GO:0006323 DNA packaging	188	before_TSS,after_TSS	36	yes	many
70	GO:0006511 ubiquitin-dependent protein catabolism	94	after_TSS	36	yes
71	GO:0007001 chromosome organization and biogenesis (sensu Eukaryota)	208	before_TSS,after_TSS	36	yes	many
72	GO:0003723 RNA binding	354	after_TSS	35		TF_PAX4,
73	GO:0007409 axonogenesis	81	after_TSS	34	yes	MIT_006SP1,
74	GO:0048598 embryonic morphogenesis	62	at_TSS,before_TSS,after_TSS	34	yes
75	GO:0007626 locomotory behavior	187	before_TSS	33	yes	MIT_081, TF_AHR,
76	GO:0016070 RNA metabolism	342	after_TSS	33		TF_PAX4,
77	GO:0006325 establishment and/or maintenance of chromatin architecture	179	before_TSS,after_TSS	32	yes	many
78	GO:0035295 tube development	61	at_TSS,before_TSS	32	yes	MIT_024MAZ, TF_CP2,
79	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway	56	at_TSS,before_TSS	32	yes	MIT_024MAZ,
80	GO:0008380 RNA splicing	154	before_TSS,after_TSS	31		TF_HTF, TF_ELK,
81	GO:0000398 nuclear mRNA splicing, via spliceosome	149	before_TSS,after_TSS	30		TF_HTF, TF_ELK,
82	GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	149	before_TSS,after_TSS	30		TF_HTF, TF_ELK,
83	GO:0000375 RNA splicing, via transesterification reactions	149	before_TSS,after_TSS	30		TF_HTF, TF_ELK,
84	GO:0009888 histogenesis	112	at_TSS	30	yes
85	GO:0004725 protein tyrosine phosphatase activity	69	at_TSS,after_TSS	30	yes
86	GO:0007507 heart development	66	after_TSS	29	yes
87	GO:0006366 transcription from RNA polymerase II promoter	231	before_TSS	29		TF_ATF6,
88	GO:0007420 brain development	63	after_TSS	29	yes
89	GO:0000910 cytokinesis	125	after_TSS	29		TF_ARNT,
90	GO:0040011 locomotion	165	before_TSS	28	yes
91	GO:0019199 transmembrane receptor protein kinase activity	60	before_TSS,after_TSS	28	yes	MIT_024MAZ, TF_AP2, TF_AP2A,
92	GO:0006813 potassium ion transport	135	before_TSS	28	yes	TF_MYOD,
93	GO:0006396 RNA processing	273	after_TSS	28		TF_PAX4,
94	GO:0005516 calmodulin binding	74	at_TSS	27	yes	many
95	GO:0009892 negative regulation of metabolism	149	before_TSS	26	yes
96	GO:0006357 regulation of transcription from RNA polymerase II promoter	191	before_TSS	26		TF_ATF6,
97	GO:0016265 death	355	at_TSS	25		MIT_030,
98	GO:0006913 nucleocytoplasmic transport	70	after_TSS	24		MIT_024MAZ,
99	GO:0006887 exocytosis	49	after_TSS	23	yes
100	GO:0051169 nuclear transport	63	after_TSS	22		MIT_024MAZ,
101	GO:0002009 morphogenesis of an epithelium	45	at_TSS,before_TSS,after_TSS	22	yes	MIT_024MAZ,
102	GO:0007179 transforming growth factor beta receptor signaling pathway	36	before_TSS	22	yes
103	GO:0016481 negative regulation of transcription	115	before_TSS,after_TSS	22	yes	TF_MAZR,
104	GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	121	before_TSS,after_TSS	22	yes	TF_MAZR,
105	GO:0007411 axon guidance	45	after_TSS	22	yes	MIT_006SP1,
106	GO:0050790 regulation of enzyme activity	107	at_TSS	21	yes	MIT_005NFY,
107	GO:0016568 chromatin modification	78	before_TSS,after_TSS	21	yes	many
108	GO:0009952 anterior/posterior pattern formation	41	at_TSS,before_TSS,after_TSS	20	yes	TF_AP2, TF_AP2A,
109	GO:0019992 diacylglycerol binding	28	at_TSS,after_TSS	20	yes

Pairs of TF_AP2 binding sites with other TFBS

No.	TFBS	Location	Total GO-s	Main GO annotation	N pairs for main GO	Total genes for main GO
1	MIT_006SP1	at_TSS,before_TSS,after_TSS	35	GO:0031323 regulation of cellular metabolism	120	1510
2	MIT_024MAZ	at_TSS,before_TSS,after_TSS	33	GO:0006350 transcription	161	1461
3	TF_MAZR	at_TSS,before_TSS,after_TSS	28	GO:0003676 nucleic acid binding	188	2302
4	TF_SP1	at_TSS,before_TSS,after_TSS	24	GO:0006512 ubiquitin cycle	128	390
5	TF_AP2	at_TSS,before_TSS,after_TSS	20	GO:0003676 nucleic acid binding	149	2302
6	TF_AP2A	at_TSS,before_TSS,after_TSS	12	GO:0016773 phosphotransferase activity, alcohol group as acceptor	105	553
7	MIT_140	before_TSS,after_TSS	10	GO:0006323 DNA packaging	22	188
8	TF_RFX1	before_TSS,after_TSS	8	GO:0006333 chromatin assembly or disassembly	13	121
9	TF_HTF	at_TSS,before_TSS,after_TSS	8	GO:0030528 transcription regulator activity	91	941
10	TF_AHR	at_TSS,before_TSS	8	GO:0030528 transcription regulator activity	121	941
11	TF_ELK	before_TSS,after_TSS	8	GO:0030528 transcription regulator activity	106	941
12	ADD_LRH	before_TSS,after_TSS	7	GO:0006334 nucleosome assembly	11	86
13	TF_ARNT	at_TSS,before_TSS,after_TSS	7	GO:0030528 transcription regulator activity	99	941
14	TF_PAX4	before_TSS,after_TSS	6	GO:0003723 RNA binding	35	354
15	TF_NF1	before_TSS	6	GO:0003677 DNA binding	84	1509
16	TF_CREB	at_TSS,before_TSS,after_TSS	6	GO:0006512 ubiquitin cycle	53	390
17	TF_RORA	after_TSS	5	GO:0044262 cellular carbohydrate metabolism	15	205
18	TF_ATF6	at_TSS,before_TSS	4	GO:0006512 ubiquitin cycle	43	390
19	TF_ATF1	at_TSS,before_TSS,after_TSS	4	GO:0006512 ubiquitin cycle	61	390
20	MIT_030	at_TSS	4	GO:0043412 biopolymer modification	67	1267
21	TF_E2F	at_TSS,before_TSS	4	GO:0006350 transcription	82	1461
22	TF_EGR1	at_TSS,before_TSS	3	GO:0003677 DNA binding	81	1509
23	TF_MYB	after_TSS	3	GO:0006397 mRNA processing	22	189
24	TF_NFY	at_TSS,before_TSS	2	GO:0030528 transcription regulator activity	53	941
25	MIT_045	at_TSS,after_TSS	2	GO:0005096 GTPase activator activity	12	93
26	TF_CP2	before_TSS,after_TSS	2	GO:0007399 nervous system development	19	301
27	MIT_031	before_TSS,after_TSS	2	GO:0004713 protein-tyrosine kinase activity	20	381
28	TF_NFKB	at_TSS	2	GO:0030554 adenyl nucleotide binding	57	1036
29	TF_P300	before_TSS,after_TSS	2	GO:0016568 chromatin modification	11	78
30	MIT_081	before_TSS	1	GO:0007626 locomotory behavior	13	187
31	TF_SREBP	after_TSS	1	GO:0009790 embryonic development	11	170
32	MIT_022	at_TSS	1	GO:0006512 ubiquitin cycle	21	390
33	TF_ARP1	after_TSS	1	GO:0051186 cofactor metabolism	14	181
34	MIT_005NFY	at_TSS	1	GO:0050790 regulation of enzyme activity	11	107
35	TF_AP4	before_TSS	1	GO:0045595 regulation of cell differentiation	10	75
36	MIT_056PAX4	before_TSS	1	GO:0045449 regulation of transcription	113	1410
37	MIT_012MYOD	before_TSS	1	GO:0030695 GTPase regulator activity	11	178
38	MIT_101	at_TSS	1	GO:0005516 calmodulin binding	10	74
39	TF_OLF1	at_TSS	1	GO:0008092 cytoskeletal protein binding	24	219
40	TF_MYOD	before_TSS	1	GO:0006813 potassium ion transport	14	135
41	MIT_035MYOD	before_TSS	1	GO:0030001 metal ion transport	23	288

Details on Gene Ontology terms for targets of TF_AP2

Total number of genes = 12103

No.	In pair with	Multi- ple	Conser- ved	Location	Frequency in list	U-clusters in list	Genes with TFBS in list, %	Genes with TFBS total, %	Ratio	z	p	FDR	GO annotation
1	none	yes		before_TSS	166	941	17.6	11.3	1.55	6.352	0	0	GO:0030528 transcription regulator activity
2	none	yes		after_TSS	145	390	37.1	23.9	1.55	6.23	0	0	GO:0006512 ubiquitin cycle
3	none	yes		before_TSS	128	719	17.8	11.3	1.57	5.639	0	0	GO:0003700 transcription factor activity
4	none			before_TSS	96	170	56.4	34.3	1.64	6.112	0	0	GO:0009790 embryonic development
5	none		yes	at_TSS	92	381	24.1	15.7	1.53	4.567	0	0.0009	GO:0004713 protein-tyrosine kinase activity
6	none	yes		at_TSS	79	553	14.2	9.1	1.55	4.256	0	0.001	GO:0016773 phosphotransferase activity, alcohol group as acceptor
7	none		yes	at_TSS	76	302	25.1	15.7	1.59	4.544	0	0.0001	GO:0005667
8	none		yes	before_TSS	70	408	17.1	10.6	1.61	4.333	0	0.0008	GO:0048519 negative regulation of biological process
9	none			before_TSS	69	128	53.9	34.3	1.56	4.68	0	0.0002	GO:0007389 pattern specification
10	none		yes	before_TSS	66	375	17.6	10.6	1.65	4.431	0	0.0008	GO:0048523 negative regulation of cellular process
11	none		yes	after_TSS	66	162	40.7	25.2	1.61	4.583	0	0.0016	GO:0048468 cell development
12	none		yes	after_TSS	65	170	38.2	25.2	1.51	3.939	0	0.0099	GO:0009790 embryonic development
13	none	yes	yes	after_TSS	64	476	13.4	8.1	1.65	4.32	0	0.0019	GO:0006468 protein amino acid phosphorylation
14	none	yes	yes	after_TSS	60	466	12.8	8.1	1.58	3.813	0.0001	0.0125	GO:0004672 protein kinase activity
15	none		yes	after_TSS	60	157	38.2	25.2	1.51	3.778	0.0001	0.0192	GO:0007167 enzyme linked receptor protein signaling pathway
16	none		yes	after_TSS	57	137	41.6	25.2	1.65	4.445	0	0.001	GO:0030182 neuron differentiation
17	none	yes	yes	after_TSS	56	381	14.6	8.1	1.8	4.758	0	0.0007	GO:0004713 protein-tyrosine kinase activity
18	none		yes	at_TSS	54	219	24.6	15.7	1.56	3.648	0.0002	0.0161	GO:0008092 cytoskeletal protein binding
19	none		yes	after_TSS	52	118	44	25.2	1.74	4.741	0	0.0003	GO:0004721 phosphoprotein phosphatase activity
20	none		yes	after_TSS	51	128	39.8	25.2	1.58	3.833	0.0001	0.0021	GO:0007389 pattern specification
21	none		yes	before_TSS	51	302	16.8	10.6	1.58	3.558	0.0003	0.0021	GO:0005667
22	none	yes	yes	after_TSS	50	408	12.2	8.1	1.5	3.093	0.0019	0.0906	GO:0048519 negative regulation of biological process
23	none	yes		before_TSS	50	288	17.3	11.3	1.53	3.264	0.001	0.0574	GO:0030001 metal ion transport
24	none	yes	yes	after_TSS	49	375	13	8.1	1.6	3.545	0.0003	0.0287	GO:0048523 negative regulation of cellular process
25	none	yes	yes	after_TSS	48	302	15.8	8.1	1.95	4.991	0	0	GO:0005667
26	none			before_TSS	48	85	56.4	34.3	1.64	4.306	0	0.006	GO:0009792 embryonic development (sensu Metazoa)
27	none	yes		after_TSS	48	118	40.6	23.9	1.69	4.282	0	0.0016	GO:0004721 phosphoprotein phosphatase activity
28	none	yes		after_TSS	46	105	43.8	23.9	1.83	4.793	0	0.0002	GO:0016311 dephosphorylation
29	none		yes	after_TSS	45	108	41.6	25.2	1.65	3.956	0	0.0069	GO:0048666 neuron development
30	none	yes	yes	after_TSS	44	330	13.3	8.1	1.63	3.499	0.0004	0.0427	GO:0051243 negative regulation of cellular physiological process
31	none		yes	after_TSS	43	99	43.4	25.2	1.72	4.193	0	0.0033	GO:0006470 protein amino acid dephosphorylation
32	none			before_TSS	43	81	53	34.3	1.54	3.559	0.0003	0.0272	GO:0016055 Wnt receptor signaling pathway
33	none			before_TSS	43	76	56.5	34.3	1.64	4.09	0	0.0039	GO:0007417 central nervous system development
34	none	yes		after_TSS	42	99	42.4	23.9	1.77	4.328	0	0.0018	GO:0006470 protein amino acid dephosphorylation
35	none	yes	yes	at_TSS	42	811	5.1	2.9	1.76	3.923	0	0.001	GO:0009653 morphogenesis
36	none		yes	at_TSS	39	157	24.8	15.7	1.57	3.144	0.0016	0.0762	GO:0007167 enzyme linked receptor protein signaling pathway
37	none		yes	after_TSS	39	96	40.6	25.2	1.61	3.492	0.0004	0.035	GO:0048667 neuron morphogensis during differentiation
38	none		yes	after_TSS	39	96	40.6	25.2	1.61	3.492	0.0004	0.035	GO:0031175 neurite morphogenesis
39	none		yes	at_TSS	38	128	29.6	15.7	1.88	4.348	0	0.0007	GO:0007389 pattern specification
40	none	yes	yes	at_TSS	38	674	5.6	2.9	1.92	4.282	0	0.0002	GO:0009887 organ morphogenesis
41	none		yes	before_TSS	37	220	16.8	10.6	1.57	2.992	0.0027	0.0483	GO:0051276 chromosome organization and biogenesis
42	none	yes	yes	after_TSS	37	273	13.5	8.1	1.66	3.309	0.0009	0.0685	GO:0016881 acid-amino acid ligase activity
43	none		yes	before_TSS	37	229	16.1	10.6	1.51	2.727	0.0063	0.0688	GO:0007610 behavior
44	none		yes	before_TSS	36	188	19.1	10.6	1.79	3.807	0.0001	0.0036	GO:0006323 DNA packaging
45	none	yes		after_TSS	36	94	38.2	23.9	1.59	3.275	0.001	0.0773	GO:0019941 modification-dependent protein catabolism
46	none	yes		after_TSS	36	94	38.2	23.9	1.59	3.275	0.001	0.0773	GO:0006511 ubiquitin-dependent protein catabolism
47	none		yes	after_TSS	36	76	47.3	25.2	1.87	4.462	0	0.0005	GO:0007417 central nervous system development
48	none		yes	before_TSS	36	208	17.3	10.6	1.62	3.139	0.0016	0.031	GO:0007001 chromosome organization and biogenesis (sensu Eukaryota)
49	none	yes		after_TSS	35	76	46	23.9	1.92	4.532	0	0.0007	GO:0007417 central nervous system development
50	none			before_TSS	34	62	54.8	34.3	1.59	3.403	0.0006	0.0348	GO:0048598 embryonic morphogenesis
51	none		yes	after_TSS	34	81	41.9	25.2	1.66	3.486	0.0004	0.0299	GO:0007409 axonogenesis
52	none		yes	after_TSS	33	81	40.7	25.2	1.61	3.23	0.0012	0.0755	GO:0016055 Wnt receptor signaling pathway
53	none			at_TSS	33	62	53.2	33.5	1.58	3.291	0.0009	0.0913	GO:0048598 embryonic morphogenesis
54	none		yes	before_TSS	33	187	17.6	10.6	1.65	3.125	0.0017	0.0382	GO:0007626 locomotory behavior
55	none		yes	after_TSS	32	62	51.6	25.2	2.04	4.8	0	0.0005	GO:0048598 embryonic morphogenesis
56	none		yes	at_TSS	32	118	27.1	15.7	1.72	3.404	0.0006	0.081	GO:0004721 phosphoprotein phosphatase activity
57	none			before_TSS	32	61	52.4	34.3	1.52	2.983	0.0028	0.087	GO:0035295 tube development
58	none			before_TSS	32	56	57.1	34.3	1.66	3.597	0.0003	0.0196	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
59	none		yes	before_TSS	32	179	17.8	10.6	1.67	3.157	0.0015	0.0307	GO:0006325 establishment and/or maintenance of chromatin architecture
60	none		yes	at_TSS	31	81	38.2	15.7	2.42	5.58	0	0	GO:0016055 Wnt receptor signaling pathway
61	none		yes	at_TSS	31	105	29.5	15.7	1.87	3.888	0.0001	0.0123	GO:0016311 dephosphorylation
62	none		yes	at_TSS	30	99	30.3	15.7	1.92	3.988	0	0.0121	GO:0006470 protein amino acid dephosphorylation
63	none		yes	at_TSS	30	112	26.7	15.7	1.69	3.218	0.0012	0.0674	GO:0009888 histogenesis
64	none	yes	yes	after_TSS	30	220	13.6	8.1	1.67	3.009	0.0026	0.0456	GO:0051276 chromosome organization and biogenesis
65	none		yes	after_TSS	30	69	43.4	25.2	1.72	3.504	0.0004	0.0559	GO:0004725 protein tyrosine phosphatase activity
66	none	yes		at_TSS	30	170	17.6	9.1	1.92	3.85	0.0001	0.0108	GO:0009790 embryonic development
67	none	yes		at_TSS	30	157	19.1	9.1	2.08	4.336	0	0.0053	GO:0007167 enzyme linked receptor protein signaling pathway
68	none	yes	yes	after_TSS	30	208	14.4	8.1	1.77	3.343	0.0008	0.0252	GO:0007001 chromosome organization and biogenesis (sensu Eukaryota)
69	none	yes	yes	after_TSS	29	188	15.4	8.1	1.89	3.682	0.0002	0.0084	GO:0006323 DNA packaging
70	none	yes		after_TSS	29	63	46	23.9	1.92	4.12	0	0.0069	GO:0007420 brain development
71	none		yes	after_TSS	29	66	43.9	25.2	1.74	3.513	0.0004	0.081	GO:0007507 heart development
72	none		yes	after_TSS	28	60	46.6	25.2	1.85	3.837	0.0001	0.0151	GO:0019199 transmembrane receptor protein kinase activity
73	none		yes	after_TSS	28	63	44.4	25.2	1.76	3.525	0.0004	0.0221	GO:0007420 brain development
74	none	yes		before_TSS	28	135	20.7	11.3	1.82	3.465	0.0005	0.0323	GO:0006813 potassium ion transport
75	none		yes	before_TSS	28	165	16.9	10.6	1.59	2.649	0.008	0.0953	GO:0040011 locomotion
76	none	yes	yes	after_TSS	27	179	15	8.1	1.85	3.423	0.0006	0.0206	GO:0006325 establishment and/or maintenance of chromatin architecture
77	none		yes	at_TSS	27	74	36.4	15.7	2.31	4.909	0	0.0003	GO:0005516 calmodulin binding
78	none			at_TSS	26	45	57.7	33.5	1.72	3.45	0.0005	0.0512	GO:0005923
79	none		yes	before_TSS	26	149	17.4	10.6	1.63	2.707	0.0067	0.0887	GO:0009892 negative regulation of metabolism
80	none	yes		after_TSS	26	62	41.9	23.9	1.75	3.329	0.0008	0.0637	GO:0048598 embryonic morphogenesis
81	none	yes		at_TSS	25	128	19.5	9.1	2.12	4.077	0	0.0083	GO:0007389 pattern specification
82	none	yes	yes	after_TSS	25	128	19.5	8.1	2.39	4.739	0	0.0001	GO:0007389 pattern specification
83	none	yes		after_TSS	23	49	46.9	23.9	1.96	3.781	0.0001	0.0142	GO:0006887 exocytosis
84	none			before_TSS	22	36	61.1	34.3	1.77	3.384	0.0007	0.0522	GO:0007179 transforming growth factor beta receptor signaling pathway
85	none		yes	at_TSS	22	76	28.9	15.7	1.83	3.166	0.0015	0.0471	GO:0007417 central nervous system development
86	none		yes	after_TSS	22	45	48.8	25.2	1.93	3.665	0.0002	0.0905	GO:0002009 morphogenesis of an epithelium
87	none		yes	before_TSS	22	121	18.1	10.6	1.7	2.699	0.0069	0.0877	GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
88	none		yes	after_TSS	22	45	48.8	25.2	1.93	3.665	0.0002	0.0905	GO:0007411 axon guidance
89	none		yes	before_TSS	22	115	19.1	10.6	1.79	2.961	0.003	0.0467	GO:0016481 negative regulation of transcription
90	none		yes	at_TSS	21	69	30.4	15.7	1.93	3.356	0.0007	0.0964	GO:0004725 protein tyrosine phosphatase activity
91	none	yes		at_TSS	21	107	19.6	9.1	2.13	3.759	0.0001	0.0624	GO:0050790 regulation of enzyme activity
92	none			at_TSS	20	28	71.4	33.5	2.12	4.251	0	0.0077	GO:0019992 diacylglycerol binding
93	none	yes		after_TSS	20	41	48.7	23.9	2.03	3.734	0.0001	0.0172	GO:0009952 anterior/posterior pattern formation
94	none	yes	yes	after_TSS	20	121	16.5	8.1	2.03	3.392	0.0006	0.0423	GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
95	none	yes	yes	at_TSS	20	301	6.6	2.9	2.26	3.864	0.0001	0.0029	GO:0007399 nervous system development
96	none	yes	yes	after_TSS	20	115	17.3	8.1	2.13	3.646	0.0002	0.0243	GO:0016481 negative regulation of transcription
97	none		yes	at_TSS	19	41	46.3	15.7	2.94	5.384	0	0	GO:0009952 anterior/posterior pattern formation
98	none		yes	at_TSS	18	51	35.2	15.7	2.23	3.837	0.0001	0.0151	GO:0045202
99	none		yes	after_TSS	18	37	48.6	25.2	1.92	3.288	0.001	0.0615	GO:0035239 tube morphogenesis
100	none			before_TSS	17	21	80.9	34.3	2.35	4.499	0	0.0024	GO:0007369 gastrulation
101	none			before_TSS	17	25	68	34.3	1.97	3.544	0.0003	0.0721	GO:0008406 gonad development
102	none			before_TSS	17	25	68	34.3	1.97	3.544	0.0003	0.0721	GO:0045137 development of primary sexual characteristics
103	none	yes	yes	before_TSS	17	302	5.6	2.3	2.37	3.768	0.0001	0.0011	GO:0005667
104	none		yes	after_TSS	17	29	58.6	25.2	2.32	4.148	0	0.0122	GO:0035107 appendage morphogenesis
105	none	yes		at_TSS	17	74	22.9	9.1	2.5	4.121	0	0.0138	GO:0005516 calmodulin binding
106	none	yes		at_TSS	17	85	20	9.1	2.17	3.467	0.0005	0.0481	GO:0009792 embryonic development (sensu Metazoa)
107	none		yes	after_TSS	17	29	58.6	25.2	2.32	4.148	0	0.0122	GO:0035108 limb morphogenesis
108	none		yes	after_TSS	16	28	57.1	25.2	2.26	3.896	0	0.0357	GO:0019992 diacylglycerol binding
109	none		yes	after_TSS	16	28	57.1	25.2	2.26	3.896	0	0.0357	GO:0030326 embryonic limb morphogenesis
110	none	yes	yes	after_TSS	16	78	20.5	8.1	2.52	4.009	0	0.0223	GO:0016568 chromatin modification
111	none		yes	after_TSS	16	28	57.1	25.2	2.26	3.896	0	0.0357	GO:0035113 embryonic appendage morphogenesis
112	none		yes	before_TSS	15	45	33.3	10.6	3.12	4.941	0	0.0001	GO:0002009 morphogenesis of an epithelium
113	none		yes	after_TSS	15	27	55.5	25.2	2.2	3.635	0.0002	0.0508	GO:0048469 cell maturation
114	none		yes	before_TSS	15	41	36.5	10.6	3.43	5.392	0	0	GO:0009952 anterior/posterior pattern formation
115	none	yes		at_TSS	14	57	24.5	9.1	2.67	4.031	0	0.0203	GO:0043085 positive regulation of enzyme activity
116	none	yes	yes	at_TSS	14	184	7.6	2.9	2.59	3.787	0.0001	0.0111	GO:0007267 cell-cell signaling
117	none		yes	before_TSS	14	60	23.3	10.6	2.19	3.192	0.0014	0.0861	GO:0019199 transmembrane receptor protein kinase activity
118	none	yes	yes	after_TSS	14	64	21.8	8.1	2.68	4.029	0	0.0102	GO:0016564 transcriptional repressor activity
119	none		yes	at_TSS	13	28	46.4	15.7	2.94	4.459	0	0.003	GO:0030326 embryonic limb morphogenesis
120	none	yes	yes	after_TSS	13	53	24.5	8.1	3.01	4.373	0	0.0022	GO:0016563 transcriptional activator activity
121	none		yes	at_TSS	13	29	44.8	15.7	2.84	4.301	0	0.0062	GO:0035107 appendage morphogenesis
122	none		yes	after_TSS	13	20	65	25.2	2.57	4.101	0	0.0075	GO:0016331 morphogenesis of embryonic epithelium
123	none		yes	at_TSS	13	28	46.4	15.7	2.94	4.459	0	0.003	GO:0035113 embryonic appendage morphogenesis
124	none		yes	at_TSS	13	29	44.8	15.7	2.84	4.301	0	0.0062	GO:0035108 limb morphogenesis
125	none	yes		at_TSS	13	56	23.2	9.1	2.52	3.645	0.0002	0.0489	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
126	none		yes	before_TSS	12	41	29.2	10.6	2.74	3.87	0.0001	0.0199	GO:0007548 sex differentiation
127	none		yes	before_TSS	12	51	23.5	10.6	2.2	2.987	0.0028	0.0793	GO:0000785
128	none	yes		at_TSS	12	41	29.2	9.1	3.18	4.462	0	0.0029	GO:0009952 anterior/posterior pattern formation
129	none		yes	before_TSS	11	37	29.7	10.6	2.79	3.767	0.0001	0.0151	GO:0035239 tube morphogenesis
130	none		yes	before_TSS	11	34	32.3	10.6	3.03	4.107	0	0.0073	GO:0007519 myogenesis
131	none	yes	yes	at_TSS	10	137	7.2	2.9	2.48	3.045	0.0023	0.0608	GO:0030182 neuron differentiation
132	ADD_LRH		yes	after_TSS	11	208	5.2	1.3	3.97	5.025	0	0.0007	GO:0007001 chromosome organization and biogenesis (sensu Eukaryota)
133	ADD_LRH		yes	after_TSS	11	188	5.8	1.3	4.39	5.452	0	0	GO:0006323 DNA packaging
134	ADD_LRH		yes	after_TSS	11	179	6.1	1.3	4.61	5.664	0	0	GO:0006325 establishment and/or maintenance of chromatin architecture
135	ADD_LRH			before_TSS	11	86	12.7	4	3.19	4.167	0	0.0103	GO:0006334 nucleosome assembly
136	ADD_LRH		yes	after_TSS	11	220	5	1.3	3.75	4.794	0	0.0023	GO:0051276 chromosome organization and biogenesis
137	ADD_LRH			before_TSS	11	88	12.5	4	3.11	4.076	0	0.0178	GO:0005694
138	ADD_LRH			before_TSS	11	95	11.5	4	2.88	3.777	0.0001	0.0504	GO:0031497 chromatin assembly
139	ADD_LRH			before_TSS	10	78	12.8	4	3.19	3.981	0	0.0247	GO:0000786
140	ADD_LRH		yes	after_TSS	10	123	8.1	1.3	6.11	6.615	0	0	GO:0006461 protein complex assembly
141	MIT_005NFY			at_TSS	11	107	10.2	2.7	3.78	4.831	0	0.0587	GO:0050790 regulation of enzyme activity
142	MIT_006SP1		yes	after_TSS	120	1510	7.9	5.1	1.54	5.281	0	0.0003	GO:0031323 regulation of cellular metabolism
143	MIT_006SP1		yes	after_TSS	119	1461	8.1	5.1	1.58	5.549	0	0	GO:0006350 transcription
144	MIT_006SP1		yes	after_TSS	116	1410	8.2	5.1	1.6	5.586	0	0	GO:0045449 regulation of transcription
145	MIT_006SP1		yes	after_TSS	116	1420	8.1	5.1	1.58	5.503	0	0.0001	GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
146	MIT_006SP1		yes	after_TSS	111	1383	8	5.1	1.56	5.166	0	0.0006	GO:0006351 transcription, DNA-dependent
147	MIT_006SP1		yes	after_TSS	110	1362	8	5.1	1.57	5.211	0	0.0005	GO:0006355 regulation of transcription, DNA-dependent
148	MIT_006SP1			at_TSS	103	390	26.4	16.9	1.55	5.058	0	0.0016	GO:0006512 ubiquitin cycle
149	MIT_006SP1			before_TSS	84	654	12.8	8.3	1.54	4.306	0	0.0798	GO:0006796 phosphate metabolism
150	MIT_006SP1			before_TSS	84	654	12.8	8.3	1.54	4.306	0	0.0798	GO:0006793 phosphorus metabolism
151	MIT_006SP1	yes		after_TSS	73	684	10.6	6.6	1.6	4.322	0	0.0954	GO:0016301 kinase activity
152	MIT_006SP1			before_TSS	66	476	13.8	8.3	1.66	4.469	0	0.0566	GO:0006468 protein amino acid phosphorylation
153	MIT_006SP1			before_TSS	64	443	14.4	8.3	1.73	4.756	0	0.0047	GO:0007049 cell cycle
154	MIT_006SP1			before_TSS	56	381	14.6	8.3	1.76	4.579	0	0.0288	GO:0004713 protein-tyrosine kinase activity
155	MIT_006SP1		yes	after_TSS	53	538	9.8	5.1	1.91	5.063	0	0.0089	GO:0030154 cell differentiation
156	MIT_006SP1	yes		at_TSS	52	315	16.5	8.9	1.85	4.791	0	0.0717	GO:0005886
157	MIT_006SP1		yes	after_TSS	43	301	14.2	5.1	2.77	7.277	0	0	GO:0007399 nervous system development
158	MIT_006SP1			before_TSS	41	246	16.6	8.3	2	4.788	0	0.0242	GO:0000074 regulation of progression through cell cycle
159	MIT_006SP1	yes		after_TSS	35	263	13.3	6.6	1.99	4.364	0	0.0551	GO:0004842 ubiquitin-protein ligase activity
160	MIT_006SP1			at_TSS	35	105	33.3	16.9	1.96	4.492	0	0.0508	GO:0016311 dephosphorylation
161	MIT_006SP1		yes	at_TSS	32	242	13.2	6.4	2.06	4.377	0	0.0577	GO:0005856
162	MIT_006SP1		yes	at_TSS	32	219	14.6	6.4	2.28	5.007	0	0.0047	GO:0008092 cytoskeletal protein binding
163	MIT_006SP1			before_TSS	31	188	16.4	8.3	1.98	4.087	0	0.0198	GO:0006323 DNA packaging
164	MIT_006SP1		yes	after_TSS	25	162	15.4	5.1	3	5.973	0	0.0001	GO:0048468 cell development
165	MIT_006SP1		yes	after_TSS	25	137	18.2	5.1	3.55	6.988	0	0	GO:0030182 neuron differentiation
166	MIT_006SP1		yes	after_TSS	22	108	20.3	5.1	3.96	7.2	0	0	GO:0048666 neuron development
167	MIT_006SP1		yes	at_TSS	21	99	21.2	6.4	3.31	6.043	0	0	GO:0006470 protein amino acid dephosphorylation
168	MIT_006SP1			before_TSS	21	78	26.9	8.3	3.23	5.967	0	0.0001	GO:0016568 chromatin modification
169	MIT_006SP1		yes	at_TSS	21	118	17.7	6.4	2.77	5.079	0	0.0163	GO:0004721 phosphoprotein phosphatase activity
170	MIT_006SP1		yes	after_TSS	18	107	16.8	5.1	3.27	5.497	0	0.0016	GO:0000904 cellular morphogenesis during differentiation
171	MIT_006SP1		yes	after_TSS	18	96	18.7	5.1	3.64	6.063	0	0	GO:0031175 neurite morphogenesis
172	MIT_006SP1		yes	after_TSS	18	96	18.7	5.1	3.64	6.063	0	0	GO:0048667 neuron morphogensis during differentiation
173	MIT_006SP1			after_TSS	17	43	39.5	15	2.62	4.489	0	0.0773	GO:0051170 nuclear import
174	MIT_006SP1			after_TSS	17	43	39.5	15	2.62	4.489	0	0.0773	GO:0006606 protein-nucleus import
175	MIT_006SP1		yes	after_TSS	16	81	19.7	5.1	3.84	5.976	0	0	GO:0007409 axonogenesis
176	MIT_006SP1		yes	after_TSS	11	45	24.4	5.1	4.75	5.875	0	0.0001	GO:0007411 axon guidance
177	MIT_006SP1	yes		after_TSS	11	49	22.4	6.6	3.36	4.437	0	0.0985	GO:0017038 protein import
178	MIT_006SP1	yes	yes	at_TSS	11	81	13.5	2.6	5.21	6.225	0	0	GO:0016055 Wnt receptor signaling pathway
179	MIT_012MYOD	yes		before_TSS	11	178	6.1	1.6	3.7	4.732	0	0.048	GO:0030695 GTPase regulator activity
180	MIT_022			at_TSS	21	390	5.3	2.2	2.36	4.174	0	0.0538	GO:0006512 ubiquitin cycle
181	MIT_024MAZ			before_TSS	161	1461	11	7.3	1.5	5.82	0	0	GO:0006350 transcription
182	MIT_024MAZ			before_TSS	155	1410	10.9	7.3	1.5	5.663	0	0	GO:0045449 regulation of transcription
183	MIT_024MAZ		yes	after_TSS	110	2046	5.3	3.3	1.58	5.425	0	0.0002	GO:0050791 regulation of physiological process
184	MIT_024MAZ		yes	after_TSS	91	1510	6	3.3	1.77	6.032	0	0	GO:0031323 regulation of cellular metabolism
185	MIT_024MAZ	yes		after_TSS	91	1509	6	3.5	1.68	5.458	0	0.0002	GO:0003677 DNA binding
186	MIT_024MAZ			after_TSS	88	508	17.3	10.9	1.58	4.693	0	0.0581	GO:0008104 protein localization
187	MIT_024MAZ			after_TSS	86	476	18	10.9	1.64	5.067	0	0.0087	GO:0015031 protein transport
188	MIT_024MAZ			after_TSS	86	478	17.9	10.9	1.64	5.024	0	0.0218	GO:0046907 intracellular transport
189	MIT_024MAZ			after_TSS	75	350	21.4	10.9	1.95	6.365	0	0	GO:0006886 intracellular protein transport
190	MIT_024MAZ		yes	at_TSS	55	811	6.7	3.2	2.06	5.795	0	0	GO:0009653 morphogenesis
191	MIT_024MAZ		yes	after_TSS	55	941	5.8	3.3	1.72	4.318	0	0.0226	GO:0030528 transcription regulator activity
192	MIT_024MAZ			before_TSS	51	408	12.5	7.3	1.71	4.103	0	0.0979	GO:0048519 negative regulation of biological process
193	MIT_024MAZ		yes	after_TSS	44	719	6.1	3.3	1.8	4.157	0	0.0516	GO:0003700 transcription factor activity
194	MIT_024MAZ			after_TSS	38	141	26.9	10.9	2.45	6.116	0	0	GO:0006605 protein targeting
195	MIT_024MAZ			before_TSS	36	246	14.6	7.3	2	4.463	0	0.0498	GO:0000074 regulation of progression through cell cycle
196	MIT_024MAZ			at_TSS	33	170	19.4	8.4	2.3	5.204	0	0.0021	GO:0009790 embryonic development
197	MIT_024MAZ		yes	at_TSS	28	301	9.3	3.2	2.83	5.939	0	0	GO:0007399 nervous system development
198	MIT_024MAZ			after_TSS	24	70	34.2	10.9	3.12	6.267	0	0	GO:0006913 nucleocytoplasmic transport
199	MIT_024MAZ			after_TSS	22	63	34.9	10.9	3.18	6.105	0	0	GO:0051169 nuclear transport
200	MIT_024MAZ		yes	after_TSS	19	208	9.1	3.3	2.68	4.609	0	0.0052	GO:0007001 chromosome organization and biogenesis (sensu Eukaryota)
201	MIT_024MAZ		yes	after_TSS	19	220	8.6	3.3	2.54	4.33	0	0.0195	GO:0051276 chromosome organization and biogenesis
202	MIT_024MAZ		yes	after_TSS	18	179	10	3.3	2.96	4.956	0	0.0011	GO:0006325 establishment and/or maintenance of chromatin architecture
203	MIT_024MAZ		yes	after_TSS	18	188	9.5	3.3	2.81	4.713	0	0.0037	GO:0006323 DNA packaging
204	MIT_024MAZ			after_TSS	17	43	39.5	10.9	3.6	6.01	0	0	GO:0006606 protein-nucleus import
205	MIT_024MAZ			after_TSS	17	49	34.6	10.9	3.16	5.33	0	0.0021	GO:0017038 protein import
206	MIT_024MAZ			after_TSS	17	43	39.5	10.9	3.6	6.01	0	0	GO:0051170 nuclear import
207	MIT_024MAZ			after_TSS	16	51	31.3	10.9	2.86	4.677	0	0.0419	GO:0003682 chromatin binding
208	MIT_024MAZ			before_TSS	15	56	26.7	7.3	3.66	5.615	0	0.0008	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
209	MIT_024MAZ			at_TSS	15	45	33.3	8.4	3.96	6.034	0	0	GO:0002009 morphogenesis of an epithelium
210	MIT_024MAZ			at_TSS	15	61	24.5	8.4	2.92	4.564	0	0.0433	GO:0035295 tube developme