Gene Ontology terms for targets of TF

CisView Mouse (mm6, March 2005)

Main Gene Ontology terms for targets of TF_AP2A

No.	GO annotation	Total genes with GO	Location	Max no. of genes with TF_AP2A	TF_AP2A alone	In pair with
1	GO:0019222 regulation of metabolism	1541	before_TSS,after_TSS	240		many
2	GO:0006350 transcription	1461	before_TSS,after_TSS	238	yes	many
3	GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	1420	at_TSS,before_TSS,after_TSS	233	yes	MIT_024MAZ, TF_AP2A, TF_MAZR,
4	GO:0045449 regulation of transcription	1410	before_TSS,after_TSS	232	yes	many
5	GO:0006351 transcription, DNA-dependent	1383	before_TSS,after_TSS	224	yes	many
6	GO:0006355 regulation of transcription, DNA-dependent	1362	before_TSS,after_TSS	221	yes	MIT_024MAZ, TF_AP2A, TF_MAZR,
7	GO:0050789 regulation of biological process	2230	after_TSS	183		MIT_024MAZ, TF_MAZR,
8	GO:0050794 regulation of cellular process	2068	after_TSS	176		MIT_024MAZ, TF_MAZR,
9	GO:0050791 regulation of physiological process	2046	after_TSS	174		MIT_024MAZ, TF_MAZR,
10	GO:0051244 regulation of cellular physiological process	1986	after_TSS	173		MIT_024MAZ, TF_MAZR,
11	GO:0031323 regulation of cellular metabolism	1510	before_TSS,after_TSS	173		MIT_024MAZ, TF_AP2A, TF_MAZR,
12	GO:0003677 DNA binding	1509	at_TSS,before_TSS,after_TSS	169		many
13	GO:0030528 transcription regulator activity	941	before_TSS,after_TSS	165	yes	many
14	GO:0006512 ubiquitin cycle	390	at_TSS,after_TSS	150	yes	many
15	GO:0004713 protein-tyrosine kinase activity	381	before_TSS,after_TSS	140	yes	TF_SP1, TF_AP2A, MIT_006SP1,
16	GO:0003676 nucleic acid binding	2302	at_TSS	140		TF_MAZR,
17	GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism	2284	after_TSS	128		MIT_024MAZ,
18	GO:0003700 transcription factor activity	719	before_TSS,after_TSS	126	yes	many
19	GO:0007399 nervous system development	301	at_TSS,after_TSS	124	yes	MIT_024MAZ, MIT_006SP1,
20	GO:0008270 zinc ion binding	901	before_TSS,after_TSS	122	yes	many
21	GO:0016773 phosphotransferase activity, alcohol group as acceptor	553	at_TSS,after_TSS	116		many
22	GO:0006468 protein amino acid phosphorylation	476	before_TSS,after_TSS	103		TF_SP1, TF_AP2A, MIT_006SP1,
23	GO:0016310 phosphorylation	549	before_TSS,after_TSS	101		TF_ZID, TF_SP1, MIT_006SP1,
24	GO:0016879 ligase activity, forming carbon-nitrogen bonds	302	after_TSS	101	yes	TF_SP1,
25	GO:0016881 acid-amino acid ligase activity	273	after_TSS	97		TF_SP1,
26	GO:0004674 protein serine/threonine kinase activity	418	before_TSS,after_TSS	96		TF_SP1, TF_AP2A, MIT_006SP1,
27	GO:0004842 ubiquitin-protein ligase activity	263	after_TSS	94		many
28	GO:0004672 protein kinase activity	466	before_TSS,after_TSS	93		TF_SP1, TF_AP2A, MIT_006SP1,
29	GO:0007275 development	1378	before_TSS	91		TF_AP2,
30	GO:0006796 phosphate metabolism	654	before_TSS	89		MIT_006SP1,
31	GO:0006793 phosphorus metabolism	654	before_TSS	89		MIT_006SP1,
32	GO:0009790 embryonic development	170	at_TSS,before_TSS	88	yes	MIT_024MAZ, TF_SP1, TF_MAZR,
33	GO:0046907 intracellular transport	478	after_TSS	85		MIT_024MAZ,
34	GO:0003723 RNA binding	354	after_TSS	84		MIT_024MAZ, TF_PAX4, MIT_006SP1,
35	GO:0046914 transition metal ion binding	1070	after_TSS	83		TF_AP2, TF_SP1,
36	GO:0016301 kinase activity	684	at_TSS,after_TSS	78		TF_AP2, TF_AP2A, MIT_006SP1,
37	GO:0006886 intracellular protein transport	350	after_TSS	74		MIT_024MAZ,
38	GO:0008092 cytoskeletal protein binding	219	at_TSS	72	yes	TF_OLF1, TF_SP1,
39	GO:0043412 biopolymer modification	1267	at_TSS	69		MIT_030,
40	GO:0007049 cell cycle	443	at_TSS,before_TSS	67		TF_SP1, TF_EGR1,
41	GO:0006464 protein modification	1178	at_TSS	67		MIT_030,
42	GO:0048519 negative regulation of biological process	408	before_TSS	67	yes
43	GO:0030695 GTPase regulator activity	178	after_TSS	66	yes	MIT_031,
44	GO:0007389 pattern specification	128	at_TSS,before_TSS,after_TSS	66	yes	MIT_081, TF_AP2A, TF_MAZR,
45	GO:0048523 negative regulation of cellular process	375	before_TSS	64	yes
46	GO:0048468 cell development	162	after_TSS	64	yes	MIT_006SP1,
47	GO:0007167 enzyme linked receptor protein signaling pathway	157	at_TSS,before_TSS,after_TSS	62	yes	MIT_024MAZ, MIT_045,
48	GO:0030182 neuron differentiation	137	at_TSS,after_TSS	58	yes	MIT_006SP1,
49	GO:0030554 adenyl nucleotide binding	1036	at_TSS	57		TF_NFKB,
50	GO:0005524 ATP binding	1011	at_TSS	56		TF_NFKB,
51	GO:0000398 nuclear mRNA splicing, via spliceosome	149	before_TSS,after_TSS	55	yes	TF_HTF, TF_ARNT, TF_ELK,
52	GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	149	before_TSS,after_TSS	55	yes	TF_HTF, TF_ARNT, TF_ELK,
53	GO:0000375 RNA splicing, via transesterification reactions	149	before_TSS,after_TSS	55	yes	TF_HTF, TF_ARNT, TF_ELK,
54	GO:0030154 cell differentiation	538	after_TSS	54		MIT_006SP1,
55	GO:0004721 phosphoprotein phosphatase activity	118	at_TSS,after_TSS	53	yes	MIT_006SP1,
56	GO:0009887 organ morphogenesis	674	at_TSS,before_TSS	52	yes	TF_AP2,
57	GO:0048513 organ development	852	before_TSS	49		TF_P300, TF_AP4, TF_HEN1,
58	GO:0016071 mRNA metabolism	202	after_TSS	47		many
59	GO:0016311 dephosphorylation	105	at_TSS,after_TSS	45	yes	TF_SP1, MIT_006SP1,
60	GO:0007417 central nervous system development	76	before_TSS,after_TSS	45	yes	MIT_140, TF_MAZR,
61	GO:0006470 protein amino acid dephosphorylation	99	at_TSS,after_TSS	44	yes	TF_SP1, MIT_006SP1,
62	GO:0006397 mRNA processing	189	before_TSS,after_TSS	43		many
63	GO:0009792 embryonic development (sensu Metazoa)	85	at_TSS,before_TSS	43	yes
64	GO:0009653 morphogenesis	811	at_TSS	42	yes
65	GO:0048666 neuron development	108	after_TSS	42	yes	MIT_006SP1,
66	GO:0007610 behavior	229	before_TSS	40	yes
67	GO:0019941 modification-dependent protein catabolism	94	after_TSS	38	yes
68	GO:0006605 protein targeting	141	after_TSS	38		MIT_024MAZ,
69	GO:0006511 ubiquitin-dependent protein catabolism	94	after_TSS	38	yes
70	GO:0000074 regulation of progression through cell cycle	246	before_TSS	38		TF_SP1, MIT_006SP1,
71	GO:0008380 RNA splicing	154	before_TSS,after_TSS	37		TF_HTF, TF_ARNT, TF_ELK,
72	GO:0016567 protein ubiquitination	227	after_TSS	35	yes
73	GO:0007420 brain development	63	before_TSS,after_TSS	34	yes
74	GO:0016055 Wnt receptor signaling pathway	81	at_TSS,after_TSS	34	yes	TF_SP1, MIT_006SP1,
75	GO:0048598 embryonic morphogenesis	62	at_TSS,before_TSS,after_TSS	34	yes	MIT_024MAZ, TF_MAZR,
76	GO:0007409 axonogenesis	81	after_TSS	33	yes	MIT_006SP1,
77	GO:0016564 transcriptional repressor activity	64	before_TSS	33	yes
78	GO:0005516 calmodulin binding	74	at_TSS,after_TSS	32	yes	MIT_101, TF_AP2, TF_MAZR,
79	GO:0006323 DNA packaging	188	before_TSS,after_TSS	32	yes	many
80	GO:0016051 carbohydrate biosynthesis	57	at_TSS	32	yes	many
81	GO:0007001 chromosome organization and biogenesis (sensu Eukaryota)	208	before_TSS,after_TSS	32	yes	MIT_130OLF1, TF_MAZR,
82	GO:0051276 chromosome organization and biogenesis	220	before_TSS,after_TSS	32	yes	MIT_130OLF1, TF_MAZR,
83	GO:0007626 locomotory behavior	187	before_TSS	32		TF_AHR, MIT_081,
84	GO:0009888 histogenesis	112	at_TSS	32	yes
85	GO:0019199 transmembrane receptor protein kinase activity	60	before_TSS,after_TSS	31	yes	TF_AP2, TF_AP2A,
86	GO:0016568 chromatin modification	78	before_TSS,after_TSS	31	yes	many
87	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway	56	at_TSS,before_TSS,after_TSS	31	yes	MIT_024MAZ,
88	GO:0040011 locomotion	165	before_TSS	30	yes	MIT_081,
89	GO:0007507 heart development	66	after_TSS	30	yes
90	GO:0004725 protein tyrosine phosphatase activity	69	at_TSS,after_TSS	30	yes
91	GO:0006928 cell motility	162	before_TSS	29	yes
92	GO:0006325 establishment and/or maintenance of chromatin architecture	179	before_TSS,after_TSS	28	yes	MIT_130OLF1, TF_MAZR,
93	GO:0016477 cell migration	141	before_TSS	27	yes
94	GO:0030145 manganese ion binding	60	after_TSS	27	yes
95	GO:0004714 transmembrane receptor protein tyrosine kinase activity	49	after_TSS	25	yes
96	GO:0006913 nucleocytoplasmic transport	70	after_TSS	24		MIT_024MAZ,
97	GO:0051186 cofactor metabolism	181	after_TSS	24		TF_RORA, TF_ARP1, ADD_LRH,
98	GO:0006887 exocytosis	49	after_TSS	23	yes
99	GO:0016481 negative regulation of transcription	115	before_TSS	23	yes	TF_MAZR,
100	GO:0051169 nuclear transport	63	after_TSS	22		MIT_024MAZ,
101	GO:0002009 morphogenesis of an epithelium	45	at_TSS,before_TSS,after_TSS	22	yes	MIT_024MAZ,
102	GO:0006732 coenzyme metabolism	159	after_TSS	22		TF_RORA, ADD_LRH,
103	GO:0009952 anterior/posterior pattern formation	41	at_TSS,before_TSS,after_TSS	21	yes	TF_AP2,
104	GO:0007179 transforming growth factor beta receptor signaling pathway	36	before_TSS	21	yes
105	GO:0005975 carbohydrate metabolism	308	at_TSS	21		TF_SREBP1,
106	GO:0019992 diacylglycerol binding	28	at_TSS,before_TSS,after_TSS	20	yes	MIT_006SP1,

Pairs of TF_AP2A binding sites with other TFBS

No.	TFBS	Location	Total GO-s	Main GO annotation	N pairs for main GO	Total genes for main GO
1	MIT_024MAZ	at_TSS,before_TSS,after_TSS	34	GO:0019222 regulation of metabolism	166	1541
2	MIT_006SP1	at_TSS,before_TSS,after_TSS	33	GO:0006512 ubiquitin cycle	103	390
3	TF_MAZR	at_TSS,before_TSS,after_TSS	32	GO:0050789 regulation of biological process	183	2230
4	TF_SP1	at_TSS,before_TSS,after_TSS	22	GO:0019222 regulation of metabolism	240	1541
5	TF_AP2A	at_TSS,before_TSS,after_TSS	19	GO:0016773 phosphotransferase activity, alcohol group as acceptor	116	553
6	TF_ARNT	at_TSS,before_TSS,after_TSS	14	GO:0006350 transcription	148	1461
7	TF_AP2	at_TSS,before_TSS,after_TSS	12	GO:0016773 phosphotransferase activity, alcohol group as acceptor	105	553
8	TF_AHR	at_TSS,before_TSS	7	GO:0006350 transcription	183	1461
9	TF_ELK	before_TSS,after_TSS	7	GO:0003677 DNA binding	85	1509
10	TF_CREB	at_TSS,after_TSS	7	GO:0006512 ubiquitin cycle	53	390
11	TF_HTF	after_TSS	6	GO:0016071 mRNA metabolism	45	202
12	MIT_130OLF1	after_TSS	5	GO:0051276 chromosome organization and biogenesis	16	220
13	TF_RORA	after_TSS	5	GO:0044262 cellular carbohydrate metabolism	15	205
14	TF_P300	at_TSS,before_TSS,after_TSS	5	GO:0048513 organ development	49	852
15	TF_ATF1	at_TSS,after_TSS	4	GO:0006512 ubiquitin cycle	60	390
16	TF_MYB	after_TSS	4	GO:0006397 mRNA processing	23	189
17	MIT_081	before_TSS	3	GO:0007626 locomotory behavior	14	187
18	TF_ATF6	at_TSS,after_TSS	3	GO:0006512 ubiquitin cycle	42	390
19	MIT_030	at_TSS	3	GO:0043412 biopolymer modification	69	1267
20	TF_NF1	before_TSS	3	GO:0019725 cell homeostasis	12	71
21	ADD_LRH	after_TSS	2	GO:0051186 cofactor metabolism	24	181
22	TF_EGR1	at_TSS,before_TSS	2	GO:0007049 cell cycle	40	443
23	TF_NFKB	at_TSS	2	GO:0030554 adenyl nucleotide binding	57	1036
24	TF_PAX4	after_TSS	1	GO:0003723 RNA binding	34	354
25	MIT_022	at_TSS	1	GO:0008565 protein transporter activity	12	120
26	TF_NFY	at_TSS	1	GO:0019207 kinase regulator activity	10	53
27	MIT_045	after_TSS	1	GO:0007167 enzyme linked receptor protein signaling pathway	11	157
28	TF_SREBP1	at_TSS	1	GO:0005975 carbohydrate metabolism	21	308
29	TF_ARP1	after_TSS	1	GO:0051186 cofactor metabolism	14	181
30	MIT_031	after_TSS	1	GO:0030695 GTPase regulator activity	13	178
31	TF_AP4	before_TSS	1	GO:0048513 organ development	47	852
32	TF_ZID	after_TSS	1	GO:0016310 phosphorylation	44	549
33	MIT_013LEF	after_TSS	1	GO:0006323 DNA packaging	10	188
34	MIT_140	after_TSS	1	GO:0007417 central nervous system development	10	76
35	MIT_056PAX4	after_TSS	1	GO:0007264 small GTPase mediated signal transduction	14	201
36	MIT_101	at_TSS	1	GO:0005516 calmodulin binding	10	74
37	TF_OLF1	at_TSS	1	GO:0008092 cytoskeletal protein binding	24	219
38	TF_HEN1	before_TSS	1	GO:0048513 organ development	49	852

Details on Gene Ontology terms for targets of TF_AP2A

Total number of genes = 12103

No.	In pair with	Multi- ple	Conser- ved	Location	Frequency in list	U-clusters in list	Genes with TFBS in list, %	Genes with TFBS total, %	Ratio	z	p	FDR	GO annotation
1	none	yes		before_TSS	238	1461	16.2	10.7	1.5	7.224	0	0	GO:0006350 transcription
2	none	yes		before_TSS	233	1420	16.4	10.7	1.52	7.262	0	0	GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
3	none	yes		before_TSS	232	1410	16.4	10.7	1.52	7.291	0	0	GO:0045449 regulation of transcription
4	none	yes		before_TSS	224	1383	16.1	10.7	1.5	6.884	0	0	GO:0006351 transcription, DNA-dependent
5	none	yes		before_TSS	221	1362	16.2	10.7	1.5	6.862	0	0	GO:0006355 regulation of transcription, DNA-dependent
6	none	yes		before_TSS	165	941	17.5	10.7	1.62	6.942	0	0	GO:0030528 transcription regulator activity
7	none	yes		after_TSS	150	390	38.4	24.4	1.57	6.535	0	0	GO:0006512 ubiquitin cycle
8	none	yes		after_TSS	140	381	36.7	24.4	1.5	5.665	0	0	GO:0004713 protein-tyrosine kinase activity
9	none	yes		before_TSS	126	719	17.5	10.7	1.62	6	0	0	GO:0003700 transcription factor activity
10	none		yes	after_TSS	124	301	41.1	25.8	1.59	6.148	0	0	GO:0007399 nervous system development
11	none	yes	yes	after_TSS	122	901	13.5	8.7	1.54	5.3	0	0	GO:0008270 zinc ion binding
12	none			before_TSS	88	170	51.7	32.8	1.57	5.298	0	0	GO:0009790 embryonic development
13	none		yes	at_TSS	78	302	25.8	16.2	1.59	4.577	0	0.0001	GO:0005667
14	none		yes	before_TSS	67	408	16.4	10.3	1.58	4.093	0	0.0017	GO:0048519 negative regulation of biological process
15	none	yes		after_TSS	66	178	37	24.4	1.51	3.943	0	0.0147	GO:0030695 GTPase regulator activity
16	none			before_TSS	66	128	51.5	32.8	1.57	4.54	0	0.0003	GO:0007389 pattern specification
17	none		yes	before_TSS	64	375	17	10.3	1.64	4.335	0	0.001	GO:0048523 negative regulation of cellular process
18	none		yes	after_TSS	64	162	39.5	25.8	1.52	3.99	0	0.006	GO:0048468 cell development
19	none		yes	after_TSS	62	157	39.4	25.8	1.52	3.922	0	0.016	GO:0007167 enzyme linked receptor protein signaling pathway
20	none	yes		before_TSS	62	381	16.2	10.7	1.5	3.504	0.0004	0.0186	GO:0004713 protein-tyrosine kinase activity
21	none		yes	after_TSS	58	137	42.3	25.8	1.63	4.426	0	0.0008	GO:0030182 neuron differentiation
22	none	yes		after_TSS	55	149	36.9	24.4	1.5	3.556	0.0003	0.0081	GO:0000375 RNA splicing, via transesterification reactions
23	none	yes		after_TSS	55	149	36.9	24.4	1.5	3.556	0.0003	0.0081	GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
24	none		yes	after_TSS	55	128	42.9	25.8	1.66	4.44	0	0.0002	GO:0007389 pattern specification
25	none	yes		after_TSS	55	149	36.9	24.4	1.5	3.556	0.0003	0.0081	GO:0000398 nuclear mRNA splicing, via spliceosome
26	none		yes	at_TSS	54	219	24.6	16.2	1.51	3.41	0.0006	0.0264	GO:0008092 cytoskeletal protein binding
27	none		yes	after_TSS	53	118	44.9	25.8	1.73	4.747	0	0.0007	GO:0004721 phosphoprotein phosphatase activity
28	none	yes	yes	after_TSS	50	302	16.5	8.7	1.89	4.869	0	0	GO:0005667
29	none	yes		after_TSS	50	118	42.3	24.4	1.73	4.547	0	0.0006	GO:0004721 phosphoprotein phosphatase activity
30	none	yes		after_TSS	45	105	42.8	24.4	1.75	4.403	0	0.0009	GO:0016311 dephosphorylation
31	none			before_TSS	45	76	59.2	32.8	1.8	4.915	0	0.0003	GO:0007417 central nervous system development
32	none		yes	after_TSS	44	99	44.4	25.8	1.71	4.237	0	0.0041	GO:0006470 protein amino acid dephosphorylation
33	none	yes	yes	after_TSS	43	302	14.2	8.7	1.62	3.424	0.0006	0.0564	GO:0016879 ligase activity, forming carbon-nitrogen bonds
34	none			before_TSS	43	85	50.5	32.8	1.54	3.501	0.0004	0.0565	GO:0009792 embryonic development (sensu Metazoa)
35	none		yes	at_TSS	43	157	27.3	16.2	1.68	3.814	0.0001	0.0166	GO:0007167 enzyme linked receptor protein signaling pathway
36	none	yes		after_TSS	42	99	42.4	24.4	1.73	4.173	0	0.0027	GO:0006470 protein amino acid dephosphorylation
37	none		yes	after_TSS	42	108	38.8	25.8	1.5	3.103	0.0019	0.0467	GO:0048666 neuron development
38	none	yes	yes	at_TSS	42	811	5.1	3.1	1.62	3.356	0.0007	0.005	GO:0009653 morphogenesis
39	none		yes	before_TSS	40	229	17.4	10.3	1.68	3.567	0.0003	0.011	GO:0007610 behavior
40	none	yes	yes	at_TSS	38	674	5.6	3.1	1.77	3.74	0.0001	0.0014	GO:0009887 organ morphogenesis
41	none	yes		after_TSS	38	94	40.4	24.4	1.65	3.613	0.0003	0.0276	GO:0006511 ubiquitin-dependent protein catabolism
42	none	yes		after_TSS	38	94	40.4	24.4	1.65	3.613	0.0003	0.0276	GO:0019941 modification-dependent protein catabolism
43	none		yes	after_TSS	37	76	48.6	25.8	1.88	4.555	0	0.0004	GO:0007417 central nervous system development
44	none		yes	at_TSS	37	128	28.9	16.2	1.78	3.907	0	0.0028	GO:0007389 pattern specification
45	none	yes		after_TSS	36	76	47.3	24.4	1.93	4.659	0	0.0011	GO:0007417 central nervous system development
46	none		yes	at_TSS	35	118	29.6	16.2	1.82	3.973	0	0.0259	GO:0004721 phosphoprotein phosphatase activity
47	none	yes	yes	after_TSS	35	227	15.4	8.7	1.76	3.595	0.0003	0.0593	GO:0016567 protein ubiquitination
48	none		yes	at_TSS	35	137	25.5	16.2	1.57	2.972	0.0029	0.0676	GO:0030182 neuron differentiation
49	none			before_TSS	34	63	53.9	32.8	1.64	3.584	0.0003	0.0247	GO:0007420 brain development
50	none			at_TSS	34	62	54.8	33.6	1.63	3.542	0.0003	0.0484	GO:0048598 embryonic morphogenesis
51	none		yes	after_TSS	34	81	41.9	25.8	1.62	3.321	0.0008	0.0656	GO:0016055 Wnt receptor signaling pathway
52	none		yes	at_TSS	34	105	32.3	16.2	1.99	4.505	0	0.0024	GO:0016311 dephosphorylation
53	none			before_TSS	33	64	51.5	32.8	1.57	3.201	0.0013	0.0556	GO:0016564 transcriptional repressor activity
54	none		yes	after_TSS	33	81	40.7	25.8	1.57	3.066	0.0021	0.0794	GO:0007409 axonogenesis
55	none	yes		after_TSS	32	81	39.5	24.4	1.61	3.159	0.0015	0.0965	GO:0016055 Wnt receptor signaling pathway
56	none		yes	after_TSS	32	74	43.2	25.8	1.67	3.423	0.0006	0.0566	GO:0005516 calmodulin binding
57	none	yes	yes	after_TSS	32	220	14.5	8.7	1.66	3.075	0.0021	0.0385	GO:0051276 chromosome organization and biogenesis
58	none			at_TSS	32	57	56.1	33.6	1.66	3.604	0.0003	0.0382	GO:0016051 carbohydrate biosynthesis
59	none		yes	at_TSS	32	112	28.5	16.2	1.75	3.556	0.0003	0.0229	GO:0009888 histogenesis
60	none	yes	yes	after_TSS	32	208	15.3	8.7	1.75	3.421	0.0006	0.0207	GO:0007001 chromosome organization and biogenesis (sensu Eukaryota)
61	none			before_TSS	32	62	51.6	32.8	1.57	3.159	0.0015	0.0643	GO:0048598 embryonic morphogenesis
62	none		yes	after_TSS	32	62	51.6	25.8	1.99	4.64	0	0.0006	GO:0048598 embryonic morphogenesis
63	none		yes	before_TSS	32	188	17	10.3	1.64	3.024	0.0024	0.0415	GO:0006323 DNA packaging
64	none		yes	at_TSS	31	81	38.2	16.2	2.35	5.395	0	0	GO:0016055 Wnt receptor signaling pathway
65	none	yes		after_TSS	31	78	39.7	24.4	1.62	3.148	0.0016	0.0601	GO:0016568 chromatin modification
66	none		yes	after_TSS	31	60	51.6	25.8	1.99	4.574	0	0.0017	GO:0019199 transmembrane receptor protein kinase activity
67	none			before_TSS	31	56	55.3	32.8	1.68	3.6	0.0003	0.0232	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
68	none	yes		after_TSS	30	63	47.6	24.4	1.94	4.286	0	0.0066	GO:0007420 brain development
69	none	yes		at_TSS	30	170	17.6	9.8	1.79	3.461	0.0005	0.0328	GO:0009790 embryonic development
70	none	yes	yes	after_TSS	30	188	15.9	8.7	1.82	3.53	0.0004	0.0126	GO:0006323 DNA packaging
71	none		yes	after_TSS	30	66	45.4	25.8	1.75	3.643	0.0002	0.0986	GO:0007507 heart development
72	none		yes	after_TSS	30	69	43.4	25.8	1.68	3.349	0.0008	0.0742	GO:0004725 protein tyrosine phosphatase activity
73	none		yes	before_TSS	30	165	18.1	10.3	1.75	3.323	0.0008	0.0191	GO:0040011 locomotion
74	none		yes	before_TSS	29	162	17.9	10.3	1.72	3.174	0.0015	0.0275	GO:0006928 cell motility
75	none		yes	after_TSS	29	63	46	25.8	1.77	3.663	0.0002	0.0152	GO:0007420 brain development
76	none	yes		at_TSS	29	157	18.4	9.8	1.88	3.673	0.0002	0.0219	GO:0007167 enzyme linked receptor protein signaling pathway
77	none	yes	yes	after_TSS	28	128	21.8	8.7	2.5	5.288	0	0	GO:0007389 pattern specification
78	none	yes	yes	after_TSS	28	179	15.6	8.7	1.78	3.293	0.0009	0.0279	GO:0006325 establishment and/or maintenance of chromatin architecture
79	none	yes		after_TSS	27	60	45	24.4	1.83	3.709	0.0002	0.038	GO:0030145 manganese ion binding
80	none		yes	before_TSS	27	141	19.1	10.3	1.84	3.448	0.0005	0.0413	GO:0016477 cell migration
81	none		yes	at_TSS	26	74	35.1	16.2	2.16	4.421	0	0.0017	GO:0005516 calmodulin binding
82	none		yes	after_TSS	25	49	51	25.8	1.97	4.028	0	0.0205	GO:0004714 transmembrane receptor protein tyrosine kinase activity
83	none	yes		at_TSS	25	128	19.5	9.8	1.99	3.718	0.0002	0.0183	GO:0007389 pattern specification
84	none		yes	at_TSS	23	69	33.3	16.2	2.05	3.862	0.0001	0.0411	GO:0004725 protein tyrosine phosphatase activity
85	none	yes		after_TSS	23	49	46.9	24.4	1.91	3.666	0.0002	0.018	GO:0006887 exocytosis
86	none	yes		before_TSS	23	115	20	10.7	1.85	3.198	0.0013	0.046	GO:0016481 negative regulation of transcription
87	none	yes	yes	at_TSS	22	364	6	3.1	1.9	3.16	0.0015	0.0824	GO:0005887
88	none		yes	after_TSS	22	45	48.8	25.8	1.88	3.532	0.0004	0.0754	GO:0002009 morphogenesis of an epithelium
89	none			before_TSS	21	36	58.3	32.8	1.77	3.265	0.001	0.0572	GO:0007179 transforming growth factor beta receptor signaling pathway
90	none	yes		after_TSS	21	41	51.2	24.4	2.09	3.991	0	0.012	GO:0009952 anterior/posterior pattern formation
91	none		yes	before_TSS	21	115	18.2	10.3	1.76	2.796	0.0051	0.0701	GO:0016481 negative regulation of transcription
92	none			at_TSS	20	28	71.4	33.6	2.12	4.237	0	0.0041	GO:0019992 diacylglycerol binding
93	none	yes	yes	at_TSS	19	301	6.3	3.1	1.98	3.134	0.0017	0.0191	GO:0007399 nervous system development
94	none		yes	at_TSS	19	51	37.2	16.2	2.29	4.078	0	0.0083	GO:0045202
95	none		yes	at_TSS	18	41	43.9	16.2	2.7	4.811	0	0.0002	GO:0009952 anterior/posterior pattern formation
96	none		yes	before_TSS	18	82	21.9	10.3	2.12	3.459	0.0005	0.0992	GO:0009966 regulation of signal transduction
97	none	yes		at_TSS	18	85	21.1	9.8	2.15	3.536	0.0004	0.0743	GO:0009792 embryonic development (sensu Metazoa)
98	none		yes	at_TSS	18	53	33.9	16.2	2.09	3.506	0.0004	0.0554	GO:0016563 transcriptional activator activity
99	none		yes	after_TSS	16	28	57.1	25.8	2.2	3.783	0.0001	0.0283	GO:0030326 embryonic limb morphogenesis
100	none		yes	after_TSS	16	29	55.1	25.8	2.13	3.607	0.0003	0.0566	GO:0035108 limb morphogenesis
101	none	yes		after_TSS	16	28	57.1	24.4	2.33	4.026	0	0.0103	GO:0019992 diacylglycerol binding
102	none		yes	before_TSS	16	61	26.2	10.3	2.53	4.08	0	0.0032	GO:0035295 tube development
103	none		yes	after_TSS	16	28	57.1	25.8	2.2	3.783	0.0001	0.0283	GO:0019992 diacylglycerol binding
104	none	yes	yes	before_TSS	16	302	5.2	2.4	2.18	3.279	0.001	0.0052	GO:0005667
105	none		yes	after_TSS	16	29	55.1	25.8	2.13	3.607	0.0003	0.0566	GO:0035107 appendage morphogenesis
106	none		yes	after_TSS	16	28	57.1	25.8	2.2	3.783	0.0001	0.0283	GO:0035113 embryonic appendage morphogenesis
107	none		yes	after_TSS	16	27	59.2	25.8	2.29	3.966	0	0.0267	GO:0048469 cell maturation
108	none		yes	before_TSS	15	60	25	10.3	2.41	3.733	0.0001	0.0138	GO:0019199 transmembrane receptor protein kinase activity
109	none			before_TSS	15	21	71.4	32.8	2.17	3.771	0.0001	0.0297	GO:0007369 gastrulation
110	none	yes		after_TSS	15	27	55.5	24.4	2.27	3.762	0.0001	0.0616	GO:0048469 cell maturation
111	none		yes	before_TSS	15	41	36.5	10.3	3.53	5.522	0	0	GO:0009952 anterior/posterior pattern formation
112	none		yes	before_TSS	15	45	33.3	10.3	3.21	5.069	0	0.0001	GO:0002009 morphogenesis of an epithelium
113	none	yes	yes	at_TSS	13	184	7	3.1	2.22	3.025	0.0024	0.0909	GO:0007267 cell-cell signaling
114	none	yes	yes	after_TSS	13	53	24.5	8.7	2.8	4.077	0	0.0033	GO:0016563 transcriptional activator activity
115	none		yes	before_TSS	13	41	31.7	10.3	3.06	4.495	0	0.0025	GO:0007548 sex differentiation
116	none	yes		at_TSS	13	56	23.2	9.8	2.36	3.38	0.0007	0.0884	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
117	none		yes	after_TSS	13	20	65	25.8	2.51	3.999	0	0.0077	GO:0016331 morphogenesis of embryonic epithelium
118	none		yes	at_TSS	12	28	42.8	16.2	2.63	3.824	0.0001	0.024	GO:0035113 embryonic appendage morphogenesis
119	none	yes		at_TSS	12	46	26	9.8	2.65	3.719	0.0002	0.0366	GO:0051336 regulation of hydrolase activity
120	none	yes	yes	after_TSS	12	56	21.4	8.7	2.45	3.369	0.0007	0.092	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
121	none	yes		after_TSS	12	21	57.1	24.4	2.33	3.486	0.0004	0.0448	GO:0007369 gastrulation
122	none		yes	at_TSS	12	29	41.3	16.2	2.54	3.675	0.0002	0.0435	GO:0035107 appendage morphogenesis
123	none		yes	at_TSS	12	29	41.3	16.2	2.54	3.675	0.0002	0.0435	GO:0035108 limb morphogenesis
124	none		yes	before_TSS	12	51	23.5	10.3	2.27	3.095	0.0019	0.06	GO:0000785
125	none		yes	at_TSS	12	28	42.8	16.2	2.63	3.824	0.0001	0.024	GO:0030326 embryonic limb morphogenesis
126	none		yes	before_TSS	11	34	32.3	10.3	3.12	4.216	0	0.0091	GO:0007519 myogenesis
127	none	yes		at_TSS	11	41	26.8	9.8	2.73	3.67	0.0002	0.0443	GO:0009952 anterior/posterior pattern formation
128	none		yes	before_TSS	11	37	29.7	10.3	2.87	3.874	0.0001	0.0195	GO:0035239 tube morphogenesis
129	none	yes		before_TSS	10	36	27.7	10.7	2.57	3.289	0.001	0.0613	GO:0007179 transforming growth factor beta receptor signaling pathway
130	none	yes	yes	before_TSS	10	170	5.8	2.4	2.42	2.945	0.0032	0.0422	GO:0009790 embryonic development
131	ADD_LRH			after_TSS	24	181	13.2	5.8	2.26	4.287	0	0.0652	GO:0051186 cofactor metabolism
132	ADD_LRH			after_TSS	22	159	13.8	5.8	2.36	4.326	0	0.0656	GO:0006732 coenzyme metabolism
133	MIT_006SP1			at_TSS	103	390	26.4	17.2	1.52	4.844	0	0.0045	GO:0006512 ubiquitin cycle
134	MIT_006SP1			before_TSS	89	654	13.6	8.1	1.66	5.208	0	0.0082	GO:0006793 phosphorus metabolism
135	MIT_006SP1			before_TSS	89	654	13.6	8.1	1.66	5.208	0	0.0082	GO:0006796 phosphate metabolism
136	MIT_006SP1			after_TSS	84	354	23.7	15.5	1.53	4.336	0	0.0313	GO:0003723 RNA binding
137	MIT_006SP1	yes		after_TSS	77	684	11.2	6.9	1.61	4.506	0	0.0713	GO:0016301 kinase activity
138	MIT_006SP1			before_TSS	76	549	13.8	8.1	1.69	4.955	0	0.0156	GO:0016310 phosphorylation
139	MIT_006SP1			before_TSS	69	476	14.4	8.1	1.77	5.129	0	0.0062	GO:0006468 protein amino acid phosphorylation
140	MIT_006SP1	yes		after_TSS	66	553	11.9	6.9	1.7	4.668	0	0.0219	GO:0016773 phosphotransferase activity, alcohol group as acceptor
141	MIT_006SP1			before_TSS	64	466	13.7	8.1	1.67	4.461	0	0.0881	GO:0004672 protein kinase activity
142	MIT_006SP1			before_TSS	61	418	14.5	8.1	1.78	4.869	0	0.0121	GO:0004674 protein serine/threonine kinase activity
143	MIT_006SP1			before_TSS	59	381	15.4	8.1	1.89	5.287	0	0.0026	GO:0004713 protein-tyrosine kinase activity
144	MIT_006SP1		yes	after_TSS	54	538	10	5.3	1.86	4.874	0	0.0157	GO:0030154 cell differentiation
145	MIT_006SP1		yes	after_TSS	42	301	13.9	5.3	2.58	6.654	0	0	GO:0007399 nervous system development
146	MIT_006SP1			before_TSS	38	246	15.4	8.1	1.88	4.201	0	0.0883	GO:0000074 regulation of progression through cell cycle
147	MIT_006SP1		yes	at_TSS	33	242	13.6	6.6	2.05	4.42	0	0.0609	GO:0005856
148	MIT_006SP1			before_TSS	29	188	15.4	8.1	1.88	3.653	0.0002	0.0974	GO:0006323 DNA packaging
149	MIT_006SP1		yes	after_TSS	23	162	14.1	5.3	2.63	4.992	0	0.0129	GO:0048468 cell development
150	MIT_006SP1		yes	after_TSS	23	137	16.7	5.3	3.11	5.935	0	0	GO:0030182 neuron differentiation
151	MIT_006SP1		yes	at_TSS	22	105	20.9	6.6	3.15	5.92	0	0.0001	GO:0016311 dephosphorylation
152	MIT_006SP1		yes	at_TSS	21	99	21.2	6.6	3.19	5.851	0	0.0001	GO:0006470 protein amino acid dephosphorylation
153	MIT_006SP1		yes	at_TSS	21	118	17.7	6.6	2.68	4.895	0	0.0212	GO:0004721 phosphoprotein phosphatase activity
154	MIT_006SP1			before_TSS	20	78	25.6	8.1	3.13	5.645	0	0.0003	GO:0016568 chromatin modification
155	MIT_006SP1		yes	after_TSS	20	108	18.5	5.3	3.43	6.063	0	0	GO:0048666 neuron development
156	MIT_006SP1			after_TSS	19	49	38.7	15.5	2.5	4.508	0	0.0942	GO:0017038 protein import
157	MIT_006SP1			after_TSS	18	43	41.8	15.5	2.69	4.781	0	0.0251	GO:0051170 nuclear import
158	MIT_006SP1			after_TSS	18	43	41.8	15.5	2.69	4.781	0	0.0251	GO:0006606 protein-nucleus import
159	MIT_006SP1		yes	after_TSS	17	96	17.7	5.3	3.28	5.36	0	0.0017	GO:0031175 neurite morphogenesis
160	MIT_006SP1		yes	after_TSS	17	107	15.8	5.3	2.94	4.825	0	0.0302	GO:0000904 cellular morphogenesis during differentiation
161	MIT_006SP1		yes	after_TSS	17	96	17.7	5.3	3.28	5.36	0	0.0017	GO:0048667 neuron morphogensis during differentiation
162	MIT_006SP1		yes	after_TSS	15	81	18.5	5.3	3.43	5.245	0	0.0033	GO:0007409 axonogenesis
163	MIT_006SP1	yes	yes	at_TSS	11	81	13.5	2.7	4.95	5.991	0	0	GO:0016055 Wnt receptor signaling pathway
164	MIT_006SP1		yes	after_TSS	10	53	18.8	5.3	3.49	4.35	0	0.098	GO:0016563 transcriptional activator activity
165	MIT_006SP1			before_TSS	10	28	35.7	8.1	4.36	5.322	0	0.0044	GO:0019992 diacylglycerol binding
166	MIT_006SP1		yes	after_TSS	10	45	22.2	5.3	4.11	5.005	0	0.012	GO:0007411 axon guidance
167	MIT_013LEF		yes	after_TSS	10	188	5.3	1.1	4.47	5.262	0	0.0002	GO:0006323 DNA packaging
168	MIT_022			at_TSS	12	120	10	2.3	4.26	5.565	0	0.0003	GO:0008565 protein transporter activity
169	MIT_024MAZ			before_TSS	166	1541	10.7	7	1.52	6.097	0	0	GO:0019222 regulation of metabolism
170	MIT_024MAZ			before_TSS	163	1510	10.7	7	1.52	6.063	0	0	GO:0031323 regulation of cellular metabolism
171	MIT_024MAZ			before_TSS	161	1461	11	7	1.56	6.308	0	0	GO:0006350 transcription
172	MIT_024MAZ			before_TSS	155	1410	10.9	7	1.55	6.141	0	0	GO:0045449 regulation of transcription
173	MIT_024MAZ			before_TSS	155	1420	10.9	7	1.54	6.044	0	0	GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
174	MIT_024MAZ			before_TSS	149	1383	10.7	7	1.52	5.736	0	0	GO:0006351 transcription, DNA-dependent
175	MIT_024MAZ			before_TSS	146	1362	10.7	7	1.51	5.603	0	0	GO:0006355 regulation of transcription, DNA-dependent
176	MIT_024MAZ	yes		after_TSS	128	2284	5.6	3.7	1.51	5.317	0	0.0007	GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism
177	MIT_024MAZ		yes	after_TSS	120	2230	5.3	3.3	1.61	5.946	0	0	GO:0050789 regulation of biological process
178	MIT_024MAZ		yes	after_TSS	114	2068	5.5	3.3	1.65	6.045	0	0	GO:0050794 regulation of cellular process
179	MIT_024MAZ		yes	after_TSS	113	2046	5.5	3.3	1.65	6.035	0	0	GO:0050791 regulation of physiological process
180	MIT_024MAZ		yes	after_TSS	112	1986	5.6	3.3	1.68	6.244	0	0	GO:0051244 regulation of cellular physiological process
181	MIT_024MAZ	yes		after_TSS	97	1509	6.4	3.7	1.73	5.971	0	0	GO:0003677 DNA binding
182	MIT_024MAZ		yes	after_TSS	89	1461	6	3.3	1.82	6.248	0	0	GO:0006350 transcription
183	MIT_024MAZ			after_TSS	85	478	17.7	10.8	1.63	4.966	0	0.0147	GO:0046907 intracellular transport
184	MIT_024MAZ			after_TSS	74	350	21.1	10.8	1.94	6.276	0	0	GO:0006886 intracellular protein transport
185	MIT_024MAZ		yes	at_TSS	74	1420	5.2	3.2	1.58	4.3	0	0.0121	GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
186	MIT_024MAZ			after_TSS	63	354	17.7	10.8	1.63	4.259	0	0.0354	GO:0003723 RNA binding
187	MIT_024MAZ		yes	after_TSS	55	941	5.8	3.3	1.75	4.457	0	0.0138	GO:0030528 transcription regulator activity
188	MIT_024MAZ		yes	after_TSS	44	719	6.1	3.3	1.83	4.281	0	0.0335	GO:0003700 transcription factor activity
189	MIT_024MAZ			after_TSS	38	141	26.9	10.8	2.48	6.178	0	0	GO:0006605 protein targeting
190	MIT_024MAZ			at_TSS	34	170	20	8.4	2.38	5.488	0	0.0005	GO:0009790 embryonic development
191	MIT_024MAZ		yes	at_TSS	28	301	9.3	3.2	2.82	5.909	0	0	GO:0007399 nervous system development
192	MIT_024MAZ			after_TSS	24	70	34.2	10.8	3.15	6.318	0	0	GO:0006913 nucleocytoplasmic transport
193	MIT_024MAZ			after_TSS	22	63	34.9	10.8	3.21	6.155	0	0	GO:0051169 nuclear transport
194	MIT_024MAZ			after_TSS	17	51	33.3	10.8	3.07	5.17	0	0.005	GO:0003682 chromatin binding
195	MIT_024MAZ			after_TSS	17	43	39.5	10.8	3.64	6.055	0	0	GO:0006606 protein-nucleus import
196	MIT_024MAZ			after_TSS	17	49	34.6	10.8	3.19	5.374	0	0.0033	GO:0017038 protein import
197	MIT_024MAZ			after_TSS	17	43	39.5	10.8	3.64	6.055	0	0	GO:0051170 nuclear import
198	MIT_024MAZ			before_TSS	15	62	24.1	7	3.42	5.282	0	0.0009	GO:0048598 embryonic morphogenesis
199	MIT_024MAZ			at_TSS	15	61	24.5	8.4	2.92	4.568	0	0.0532	GO:0035295 tube development
200	MIT_024MAZ			at_TSS	15	45	33.3	8.4	3.96	6.039	0	0	GO:0002009 morphogenesis of an epithelium
201	MIT_024MAZ			before_TSS	14	56	25	7	3.54	5.255	0	0.0031	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
202	MIT_024MAZ	yes		before_TSS	13	157	8.2	2.3	3.54	4.958	0	0.0307	GO:0007167 enzyme linked receptor protein signaling pathway
203	MIT_024MAZ			at_TSS	11	37	29.7	8.4	3.53	4.682	0	0.0245	GO:0035239 tube morphogenesis
204	MIT_024MAZ	yes		after_TSS	11	78	14.1	3.7	3.8	4.871	0	0.0095	GO:0016568 chromatin modification
205	MIT_030			at_TSS	69	1267	5.4	2.9	1.85	5.601	0	0.0001	GO:0043412 biopolymer modification
206	MIT_030			at_TSS	67	1178	5.6	2.9	1.93	5.896	0	0	GO:0006464 protein modification
207	MIT_030			at_TSS	29	390	7.4	2.9	2.53	5.356	0	0.0007	GO:0006512 ubiquitin cycle
208	MIT_031			after_TSS	13	178	7.3	2.1	3.32	4.68	0	0.0619	GO:0030695 GTPase regulator activity
209	MIT_045		yes	after_TSS	11	157	7	1.8	3.85	4.898	0	0.0418	GO:0007167 enzyme linked receptor protein signaling pathway
210	MIT_056PAX4	yes		after_TSS	14	201	6.9	2.1	3.24	4.749	0	0.0883	GO:0007264 small GTPase mediated signal transduction
211	MIT_081			before_TSS	14	187	7.4	2.1	3.4	4.971	0	0.0287	GO:0007626 locomotory behavior
212	MIT_081		&nbs