CisView Mouse (mm6, March 2005)

Main Gene Ontology terms for targets of TF_HNF3

No.GO annotation
Total
genes
with GO
Location
Max no. of
genes with
TF_HNF3
TF_HNF3 alone
In pair
with
1GO:0048513 organ development
852
before_TSS
96
yes
 
2GO:0009653 morphogenesis
811
before_TSS
90
yes
 
3GO:0009887 organ morphogenesis
674
before_TSS
82
yes
 
4GO:0003700 transcription factor activity
719
before_TSS
74
yes
 
5GO:0003735 structural constituent of ribosome
172
before_TSS
60
yes
 
6GO:0001584 rhodopsin-like receptor activity
283
after_TSS
46
yes
 
7GO:0048519 negative regulation of biological process
408
before_TSS
43
yes
MIT_024MAZ, MIT_006SP1,
8GO:0009607 response to biotic stimulus
483
at_TSS
42
yes
 
9GO:0006952 defense response
463
at_TSS
42
yes
 
10GO:0009605 response to external stimulus
489
at_TSS,after_TSS
42
yes
 
11GO:0004175 endopeptidase activity
397
before_TSS
41
 
TF_FOXD,
12GO:0048523 negative regulation of cellular process
375
before_TSS
40
yes
MIT_024MAZ,
13GO:0007399 nervous system development
301
before_TSS
39
yes
 
14GO:0043118 negative regulation of physiological process
342
before_TSS
38
yes
MIT_024MAZ, MIT_006SP1,
15GO:0005102 receptor binding
406
at_TSS
36
yes
 
16GO:0051243 negative regulation of cellular physiological process
330
before_TSS
36
yes
MIT_024MAZ,
17GO:0006955 immune response
379
at_TSS
34
yes
 
18GO:0016779 nucleotidyltransferase activity
91
before_TSS
32
yes
 
19GO:0004857 enzyme inhibitor activity
155
after_TSS
30
yes
 
20GO:0006082 organic acid metabolism
350
before_TSS
30
 
TF_SREBP, TF_IK,
21GO:0019752 carboxylic acid metabolism
350
before_TSS
30
 
TF_SREBP, TF_IK,
22GO:0006118 electron transport
329
before_TSS
26
 
MIT_062,
23GO:0030246 carbohydrate binding
208
at_TSS
25
yes
 
24GO:0004866 endopeptidase inhibitor activity
112
after_TSS
24
yes
 
25GO:0030414 protease inhibitor activity
112
after_TSS
24
yes
 
26GO:0043207 response to external biotic stimulus
237
at_TSS
23
yes
 
27GO:0005179 hormone activity
97
after_TSS
21
yes
 
28GO:0009613 response to pest, pathogen or parasite
221
at_TSS
21
yes
 
29GO:0007167 enzyme linked receptor protein signaling pathway
157
before_TSS
21
yes
 
30GO:0009611 response to wounding
180
at_TSS
20
yes
 
31GO:0009892 negative regulation of metabolism
149
before_TSS
20
yes
 
32GO:0004867 serine-type endopeptidase inhibitor activity
77
after_TSS
20
yes
 
33GO:0000398 nuclear mRNA splicing, via spliceosome
149
before_TSS
19
 
MIT_093PITX,
34GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
149
before_TSS
19
 
MIT_093PITX,
35GO:0000375 RNA splicing, via transesterification reactions
149
before_TSS
19
 
MIT_093PITX,
36GO:0009888 histogenesis
112
before_TSS
18
yes
 
37GO:0009893 positive regulation of metabolism
137
at_TSS
17
yes
 
38GO:0031324 negative regulation of cellular metabolism
132
before_TSS
17
yes
 
39GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
121
before_TSS
17
yes
 
40GO:0031325 positive regulation of cellular metabolism
134
at_TSS
17
yes
 
41GO:0016481 negative regulation of transcription
115
before_TSS
16
yes
 
42GO:0007389 pattern specification
128
before_TSS
15
yes
 
43GO:0007417 central nervous system development
76
before_TSS
15
yes
 
44GO:0001614 purinergic nucleotide receptor activity
53
after_TSS
14
yes
 
45GO:0001608 nucleotide receptor activity, G-protein coupled
53
after_TSS
14
yes
 
46GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
53
after_TSS
14
yes
 
47GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
91
before_TSS
14
 
MIT_062, TF_MRF2,
48GO:0016502 nucleotide receptor activity
53
after_TSS
14
yes
 
49GO:0045595 regulation of cell differentiation
75
before_TSS
14
yes
 
50GO:0007600 sensory perception
196
after_TSS
13
yes
 
51GO:0007420 brain development
63
before_TSS
13
yes
 
52GO:0016564 transcriptional repressor activity
64
before_TSS
13
yes
 
53GO:0031497 chromatin assembly
95
at_TSS
12
yes
 
54GO:0006366 transcription from RNA polymerase II promoter
231
at_TSS
12
yes
 
55GO:0001501 skeletal development
87
before_TSS
12
yes
 
56GO:0046849 bone remodeling
53
before_TSS
11
yes
 
57GO:0006334 nucleosome assembly
86
at_TSS
11
yes
 
58GO:0016789 carboxylic ester hydrolase activity
80
at_TSS
11
yes
 
59GO:0008380 RNA splicing
154
before_TSS
11
 
MIT_093PITX,
60GO:0016042 lipid catabolism
61
at_TSS,before_TSS
11
yes
TF_MYC,
61GO:0030247 polysaccharide binding
68
at_TSS
11
yes
 
62GO:0001871 pattern binding
70
at_TSS
11
yes
 
63GO:0004879 ligand-dependent nuclear receptor activity
45
before_TSS
10
yes
 
64GO:0001503 ossification
48
before_TSS
10
yes
 
65GO:0031214 biomineral formation
48
before_TSS
10
yes
 
66GO:0005529 sugar binding
144
after_TSS
10
yes
 
67GO:0003707 steroid hormone receptor activity
45
before_TSS
10
yes
 
68GO:0005539 glycosaminoglycan binding
60
at_TSS
10
yes
 
69GO:0004497 monooxygenase activity
90
before_TSS
10
 
MIT_062,
70GO:0000122 negative regulation of transcription from RNA polymerase II promoter
62
before_TSS
10
yes
 
71GO:0030900 forebrain development
31
before_TSS
10
yes
 
72GO:0006357 regulation of transcription from RNA polymerase II promoter
191
at_TSS
10
yes
 
73GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
56
before_TSS
10
yes
 

Pairs of TF_HNF3 binding sites with other TFBS

No.TFBS
Location
Total GO-s
Main GO annotation
N pairs for
main GO
Total genes
for main GO
1MIT_024MAZ
before_TSS
4
GO:0048519 negative regulation of biological process
36
408
2MIT_093PITX
before_TSS
4
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
19
149
3MIT_062
before_TSS
3
GO:0006118 electron transport
26
329
4TF_SREBP
before_TSS
2
GO:0019752 carboxylic acid metabolism
30
350
5TF_IK
before_TSS
2
GO:0019752 carboxylic acid metabolism
23
350
6MIT_006SP1
before_TSS
2
GO:0048519 negative regulation of biological process
21
408
7TF_MRF2
before_TSS
1
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
14
91
8TF_MYC
before_TSS
1
GO:0016042 lipid catabolism
11
61
9TF_FOXD
before_TSS
1
GO:0004175 endopeptidase activity
41
397

Details on Gene Ontology terms for targets of TF_HNF3

Total number of genes = 12103
No.In pair
with
Multi-
ple
Conser-
ved
Location
Frequency
in list
U-clusters
in list
Genes with TFBS
in list, %
Genes with TFBS
total, %
Ratio
z
p
FDR
GO annotation
1none
 
yes
before_TSS
96
852
11.2
6.4
1.75
5.973
0
0
GO:0048513 organ development
2none
 
yes
before_TSS
90
811
11
6.4
1.72
5.612
0
0
GO:0009653 morphogenesis
3none
 
yes
before_TSS
82
674
12.1
6.4
1.89
6.25
0
0
GO:0009887 organ morphogenesis
4none
 
yes
before_TSS
74
719
10.2
6.4
1.6
4.355
0
0
GO:0003700 transcription factor activity
5none
yes
 
before_TSS
60
172
34.8
21.6
1.61
4.258
0
0.0018
GO:0003735 structural constituent of ribosome
6none
 
 
after_TSS
46
283
16.2
10.7
1.5
2.997
0.0027
0.0321
GO:0001584 rhodopsin-like receptor activity
7none
yes
 
before_TSS
45
136
33
21.6
1.53
3.269
0.001
0.0658
GO:0005840
8none
 
yes
before_TSS
43
408
10.5
6.4
1.63
3.444
0.0005
0.0131
GO:0048519 negative regulation of biological process
9none
 
 
at_TSS
42
483
8.6
5.6
1.55
3.017
0.0025
0.0183
GO:0009607 response to biotic stimulus
10none
 
 
at_TSS
42
489
8.5
5.6
1.53
2.932
0.0033
0.0286
GO:0009605 response to external stimulus
11none
 
 
at_TSS
42
463
9
5.6
1.61
3.31
0.0009
0.0075
GO:0006952 defense response
12none
 
yes
before_TSS
40
375
10.6
6.4
1.65
3.399
0.0006
0.0165
GO:0048523 negative regulation of cellular process
13none
 
yes
before_TSS
39
301
12.9
6.4
2.01
4.676
0
0
GO:0007399 nervous system development
14none
 
yes
before_TSS
38
342
11.1
6.4
1.72
3.581
0.0003
0.0113
GO:0043118 negative regulation of physiological process
15none
 
 
at_TSS
36
406
8.8
5.6
1.58
2.91
0.0036
0.0661
GO:0005102 receptor binding
16none
 
yes
before_TSS
36
330
10.9
6.4
1.69
3.365
0.0007
0.02
GO:0051243 negative regulation of cellular physiological process
17none
 
 
at_TSS
34
379
8.9
5.6
1.6
2.897
0.0037
0.0313
GO:0006955 immune response
18none
 
yes
before_TSS
33
302
10.9
6.4
1.69
3.228
0.0012
0.006
GO:0005667
19none
 
 
at_TSS
32
356
8.9
5.6
1.6
2.82
0.0048
0.0418
GO:0005576
20none
yes
 
before_TSS
32
91
35.1
21.6
1.62
3.152
0.0016
0.0989
GO:0016779 nucleotidyltransferase activity
21none
 
 
after_TSS
30
155
19.3
10.7
1.79
3.458
0.0005
0.0181
GO:0004857 enzyme inhibitor activity
22none
yes
 
after_TSS
26
489
5.3
3
1.74
2.977
0.0029
0.0169
GO:0009605 response to external stimulus
23none
 
 
at_TSS
25
208
12
5.6
2.14
4.059
0
0.009
GO:0030246 carbohydrate binding
24none
 
 
after_TSS
24
112
21.4
10.7
1.98
3.645
0.0002
0.0097
GO:0004866 endopeptidase inhibitor activity
25none
 
 
after_TSS
24
112
21.4
10.7
1.98
3.645
0.0002
0.0097
GO:0030414 protease inhibitor activity
26none
 
 
at_TSS
23
237
9.7
5.6
1.73
2.773
0.0055
0.0495
GO:0043207 response to external biotic stimulus
27none
 
yes
before_TSS
21
157
13.3
6.4
2.08
3.572
0.0003
0.0185
GO:0007167 enzyme linked receptor protein signaling pathway
28none
 
 
after_TSS
21
97
21.6
10.7
2
3.46
0.0005
0.0109
GO:0005179 hormone activity
29none
 
 
at_TSS
21
221
9.5
5.6
1.69
2.544
0.0109
0.0932
GO:0009613 response to pest, pathogen or parasite
30none
 
 
at_TSS
20
180
11.1
5.6
1.98
3.238
0.0012
0.04
GO:0009611 response to wounding
31none
 
 
after_TSS
20
77
25.9
10.7
2.4
4.307
0
0.003
GO:0004867 serine-type endopeptidase inhibitor activity
32none
 
yes
before_TSS
20
149
13.4
6.4
2.08
3.502
0.0004
0.012
GO:0009892 negative regulation of metabolism
33none
 
yes
before_TSS
18
112
16
6.4
2.5
4.18
0
0.0053
GO:0009888 histogenesis
34none
 
 
at_TSS
17
137
12.4
5.6
2.21
3.484
0.0004
0.0602
GO:0009893 positive regulation of metabolism
35none
 
 
at_TSS
17
134
12.6
5.6
2.26
3.586
0.0003
0.0409
GO:0031325 positive regulation of cellular metabolism
36none
 
yes
before_TSS
17
121
14
6.4
2.18
3.435
0.0005
0.0154
GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
37none
 
yes
before_TSS
17
132
12.8
6.4
2
3.038
0.0023
0.0512
GO:0031324 negative regulation of cellular metabolism
38none
 
yes
before_TSS
16
115
13.9
6.4
2.16
3.288
0.001
0.0205
GO:0016481 negative regulation of transcription
39none
 
yes
before_TSS
15
76
19.7
6.4
3.07
4.745
0
0
GO:0007417 central nervous system development
40none
 
yes
before_TSS
15
128
11.7
6.4
1.82
2.453
0.0141
0.074
GO:0007389 pattern specification
41none
 
 
after_TSS
14
53
26.4
10.7
2.44
3.674
0.0002
0.0218
GO:0001608 nucleotide receptor activity, G-protein coupled
42none
 
 
after_TSS
14
53
26.4
10.7
2.44
3.674
0.0002
0.0218
GO:0001614 purinergic nucleotide receptor activity
43none
 
yes
before_TSS
14
75
18.6
6.4
2.9
4.334
0
0.0053
GO:0045595 regulation of cell differentiation
44none
 
 
after_TSS
14
53
26.4
10.7
2.44
3.674
0.0002
0.0218
GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
45none
 
 
after_TSS
14
53
26.4
10.7
2.44
3.674
0.0002
0.0218
GO:0016502 nucleotide receptor activity
46none
yes
 
after_TSS
13
196
6.6
3
2.17
2.942
0.0032
0.0477
GO:0007600 sensory perception
47none
 
yes
before_TSS
13
63
20.6
6.4
3.21
4.609
0
0.0001
GO:0007420 brain development
48none
 
yes
before_TSS
13
64
20.3
6.4
3.15
4.54
0
0.0006
GO:0016564 transcriptional repressor activity
49none
 
 
at_TSS
12
95
12.6
5.6
2.25
2.991
0.0027
0.0407
GO:0031497 chromatin assembly
50none
 
yes
before_TSS
12
87
13.7
6.4
2.14
2.811
0.0049
0.0951
GO:0001501 skeletal development
51none
 
yes
at_TSS
12
231
5.1
1.8
2.84
3.861
0.0001
0.0103
GO:0006366 transcription from RNA polymerase II promoter
52none
 
 
at_TSS
11
68
16.1
5.6
2.88
3.802
0.0001
0.0262
GO:0030247 polysaccharide binding
53none
 
 
at_TSS
11
80
13.7
5.6
2.45
3.179
0.0014
0.0772
GO:0016789 carboxylic ester hydrolase activity
54none
 
yes
before_TSS
11
53
20.7
6.4
3.22
4.261
0
0.0037
GO:0046849 bone remodeling
55none
 
 
at_TSS
11
70
15.7
5.6
2.8
3.689
0.0002
0.0412
GO:0001871 pattern binding
56none
 
 
at_TSS
11
86
12.7
5.6
2.28
2.909
0.0036
0.0552
GO:0006334 nucleosome assembly
57none
 
 
at_TSS
11
88
12.5
5.6
2.23
2.824
0.0047
0.0789
GO:0005694
58none
 
yes
before_TSS
10
31
32.2
6.4
5.01
5.871
0
0
GO:0030900 forebrain development
59none
 
yes
before_TSS
10
45
22.2
6.4
3.45
4.327
0
0.0055
GO:0003707 steroid hormone receptor activity
60none
 
 
at_TSS
10
78
12.8
5.6
2.28
2.781
0.0054
0.0901
GO:0000786
61none
 
yes
before_TSS
10
62
16.1
6.4
2.5
3.122
0.0017
0.0939
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
62none
 
 
at_TSS
10
61
16.3
5.6
2.92
3.674
0.0002
0.0291
GO:0016042 lipid catabolism
63none
 
yes
before_TSS
10
45
22.2
6.4
3.45
4.327
0
0.0055
GO:0004879 ligand-dependent nuclear receptor activity
64none
 
yes
before_TSS
10
48
20.8
6.4
3.24
4.077
0
0.0083
GO:0031214 biomineral formation
65none
 
yes
before_TSS
10
56
17.8
6.4
2.77
3.495
0.0004
0.0433
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
66none
 
yes
before_TSS
10
48
20.8
6.4
3.24
4.077
0
0.0083
GO:0001503 ossification
67none
 
yes
at_TSS
10
191
5.2
1.8
2.86
3.547
0.0003
0.0475
GO:0006357 regulation of transcription from RNA polymerase II promoter
68none
yes
 
after_TSS
10
144
6.9
3
2.27
2.735
0.0062
0.0652
GO:0005529 sugar binding
69none
 
yes
before_TSS
10
51
19.6
6.4
3.05
3.845
0.0001
0.0073
GO:0000785
70none
 
 
at_TSS
10
60
16.6
5.6
2.97
3.736
0.0001
0.0342
GO:0005539 glycosaminoglycan binding
71MIT_006SP1
 
 
before_TSS
21
408
5.1
2
2.5
4.472
0
0.0372
GO:0048519 negative regulation of biological process
72MIT_006SP1
 
 
before_TSS
18
342
5.2
2
2.55
4.236
0
0.0756
GO:0043118 negative regulation of physiological process
73MIT_024MAZ
 
 
before_TSS
36
408
8.8
4.1
2.14
4.871
0
0.0119
GO:0048519 negative regulation of biological process
74MIT_024MAZ
 
 
before_TSS
35
375
9.3
4.1
2.26
5.168
0
0.0051
GO:0048523 negative regulation of cellular process
75MIT_024MAZ
 
 
before_TSS
33
342
9.6
4.1
2.34
5.226
0
0.0037
GO:0043118 negative regulation of physiological process
76MIT_024MAZ
 
 
before_TSS
32
330
9.6
4.1
2.35
5.176
0
0.0032
GO:0051243 negative regulation of cellular physiological process
77MIT_062
 
 
before_TSS
26
329
7.9
2.8
2.8
5.651
0
0.0006
GO:0006118 electron transport
78MIT_062
 
 
before_TSS
10
91
10.9
2.8
3.9
4.728
0
0.0244
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
79MIT_062
 
 
before_TSS
10
90
11.1
2.8
3.94
4.772
0
0.0131
GO:0004497 monooxygenase activity
80MIT_093PITX
 
 
before_TSS
19
149
12.7
5.1
2.48
4.234
0
0.0826
GO:0000375 RNA splicing, via transesterification reactions
81MIT_093PITX
 
 
before_TSS
19
149
12.7
5.1
2.48
4.234
0
0.0826
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
82MIT_093PITX
 
 
before_TSS
19
149
12.7
5.1
2.48
4.234
0
0.0826
GO:0000398 nuclear mRNA splicing, via spliceosome
83MIT_093PITX
yes
 
before_TSS
11
149
7.3
1.7
4.15
5.212
0
0.008
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
84MIT_093PITX
yes
 
before_TSS
11
149
7.3
1.7
4.15
5.212
0
0.008
GO:0000398 nuclear mRNA splicing, via spliceosome
85MIT_093PITX
yes
 
before_TSS
11
149
7.3
1.7
4.15
5.212
0
0.008
GO:0000375 RNA splicing, via transesterification reactions
86MIT_093PITX
yes
 
before_TSS
11
154
7.1
1.7
4.02
5.073
0
0.0084
GO:0008380 RNA splicing
87TF_FOXD
yes
 
before_TSS
41
397
10.3
5.2
1.97
4.649
0
0.048
GO:0004175 endopeptidase activity
88TF_IK
 
 
before_TSS
23
350
6.5
2.8
2.29
4.229
0
0.0596
GO:0019752 carboxylic acid metabolism
89TF_IK
 
 
before_TSS
23
350
6.5
2.8
2.29
4.229
0
0.0596
GO:0006082 organic acid metabolism
90TF_MRF2
 
 
before_TSS
14
91
15.3
4.9
3.11
4.614
0
0.0341
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
91TF_MYC
 
 
before_TSS
11
61
18
5
3.59
4.669
0
0.0654
GO:0016042 lipid catabolism
92TF_SREBP
 
 
before_TSS
30
350
8.5
4
2.13
4.393
0
0.0402
GO:0019752 carboxylic acid metabolism
93TF_SREBP
 
 
before_TSS
30
350
8.5
4
2.13
4.393
0
0.0402
GO:0006082 organic acid metabolism
94TF_SREBP
 
 
before_TSS
10
60
16.6
4
4.14
4.995
0
0.0127
GO:0009897