CisView Mouse (mm6, March 2005)

Main Gene Ontology terms for targets of TF_MYC

No.GO annotation
Total
genes
with GO
Location
Max no. of
genes with
TF_MYC
TF_MYC alone
In pair
with
1GO:0030528 transcription regulator activity
941
at_TSS,before_TSS
84
yes
 
2GO:0016070 RNA metabolism
342
after_TSS
75
yes
TF_GABP,
3GO:0003700 transcription factor activity
719
at_TSS
70
yes
 
4GO:0006396 RNA processing
273
after_TSS
59
yes
TF_AHR,
5GO:0016310 phosphorylation
549
before_TSS
46
yes
 
6GO:0030154 cell differentiation
538
before_TSS
46
yes
 
7GO:0006468 protein amino acid phosphorylation
476
before_TSS
40
yes
 
8GO:0003735 structural constituent of ribosome
172
before_TSS,after_TSS
38
yes
MIT_174,
9GO:0003723 RNA binding
354
after_TSS
36
yes
 
10GO:0016741 transferase activity, transferring one-carbon groups
101
after_TSS
32
yes
TF_ELK,
11GO:0008168 methyltransferase activity
98
after_TSS
31
yes
TF_ELK,
12GO:0043037 translation
128
after_TSS
30
yes
 
13GO:0007399 nervous system development
301
before_TSS
30
yes
 
14GO:0006399 tRNA metabolism
86
after_TSS
23
yes
 
15GO:0016071 mRNA metabolism
202
after_TSS
22
yes
 
16GO:0042254 ribosome biogenesis and assembly
74
after_TSS
20
yes
 
17GO:0007389 pattern specification
128
at_TSS
19
yes
 
18GO:0000398 nuclear mRNA splicing, via spliceosome
149
after_TSS
18
yes
 
19GO:0008135 translation factor activity, nucleic acid binding
86
at_TSS,after_TSS
18
yes
 
20GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
149
after_TSS
18
yes
 
21GO:0000375 RNA splicing, via transesterification reactions
149
after_TSS
18
yes
 
22GO:0045182 translation regulator activity
90
at_TSS,after_TSS
18
yes
 
23GO:0005342 organic acid transporter activity
68
at_TSS
17
yes
 
24GO:0016887 ATPase activity
280
after_TSS
17
 
TF_ELK,
25GO:0048037 cofactor binding
53
after_TSS
17
yes
 
26GO:0046943 carboxylic acid transporter activity
68
at_TSS
17
yes
 
27GO:0046483 heterocycle metabolism
53
after_TSS
16
yes
 
28GO:0009892 negative regulation of metabolism
149
before_TSS
16
yes
 
29GO:0031324 negative regulation of cellular metabolism
132
before_TSS
15
yes
 
30GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
121
before_TSS
15
yes
 
31GO:0030182 neuron differentiation
137
before_TSS
15
yes
 
32GO:0016481 negative regulation of transcription
115
before_TSS
14
yes
 
33GO:0016072 rRNA metabolism
31
at_TSS,after_TSS
14
yes
 
34GO:0050662 coenzyme binding
44
after_TSS
14
yes
 
35GO:0006364 rRNA processing
29
after_TSS
13
yes
 
36GO:0008033 tRNA processing
32
after_TSS
12
yes
 
37GO:0007420 brain development
63
before_TSS
11
yes
 
38GO:0016042 lipid catabolism
61
before_TSS
11
 
TF_HNF3, TF_FOXD,
39GO:0007417 central nervous system development
76
before_TSS
11
yes
 
40GO:0046942 carboxylic acid transport
55
at_TSS
10
yes
 
41GO:0050790 regulation of enzyme activity
107
before_TSS
10
 
TF_PAX4,
42GO:0016829 lyase activity
121
at_TSS
10
 
TF_NFY,
43GO:0007276 gametogenesis
119
before_TSS
10
 
TF_MYB,
44GO:0015849 organic acid transport
55
at_TSS
10
yes
 

Pairs of TF_MYC binding sites with other TFBS

No.TFBS
Location
Total GO-s
Main GO annotation
N pairs for
main GO
Total genes
for main GO
1TF_ELK
after_TSS
3
GO:0016887 ATPase activity
17
280
2TF_PAX4
before_TSS
1
GO:0050790 regulation of enzyme activity
10
107
3TF_HNF3
before_TSS
1
GO:0016042 lipid catabolism
11
61
4TF_MYB
before_TSS
1
GO:0007276 gametogenesis
10
119
5TF_FOXD
before_TSS
1
GO:0016042 lipid catabolism
11
61
6TF_NFY
at_TSS
1
GO:0016829 lyase activity
10
121
7TF_GABP
after_TSS
1
GO:0016070 RNA metabolism
18
342
8TF_AHR
after_TSS
1
GO:0006396 RNA processing
22
273
9MIT_174
before_TSS
1
GO:0003735 structural constituent of ribosome
10
172

Details on Gene Ontology terms for targets of TF_MYC

Total number of genes = 12103
No.In pair
with
Multi-
ple
Conser-
ved
Location
Frequency
in list
U-clusters
in list
Genes with TFBS
in list, %
Genes with TFBS
total, %
Ratio
z
p
FDR
GO annotation
1none
 
yes
at_TSS
84
941
8.9
5.8
1.52
4.173
0
0.0002
GO:0030528 transcription regulator activity
2none
 
yes
before_TSS
78
941
8.2
5.4
1.52
4.047
0
0.0002
GO:0030528 transcription regulator activity
3none
 
 
after_TSS
75
342
21.9
13.6
1.6
4.496
0
0.0001
GO:0016070 RNA metabolism
4none
 
yes
at_TSS
70
719
9.7
5.8
1.66
4.565
0
0
GO:0003700 transcription factor activity
5none
 
 
after_TSS
59
273
21.6
13.6
1.57
3.85
0.0001
0.0025
GO:0006396 RNA processing
6none
 
yes
before_TSS
46
538
8.5
5.4
1.57
3.28
0.001
0.0126
GO:0030154 cell differentiation
7none
 
yes
before_TSS
46
549
8.3
5.4
1.54
3.133
0.0017
0.0527
GO:0016310 phosphorylation
8none
 
yes
before_TSS
40
476
8.4
5.4
1.55
2.932
0.0033
0.077
GO:0006468 protein amino acid phosphorylation
9none
 
 
after_TSS
39
183
21.3
13.6
1.55
3.021
0.0025
0.0512
GO:0030529
10none
 
 
after_TSS
38
172
22
13.6
1.61
3.228
0.0012
0.0414
GO:0003735 structural constituent of ribosome
11none
 
yes
after_TSS
36
354
10.1
5.5
1.84
3.907
0
0.0171
GO:0003723 RNA binding
12none
 
 
after_TSS
32
136
23.5
13.6
1.71
3.356
0.0007
0.0723
GO:0005840
13none
 
 
after_TSS
32
101
31.6
13.6
2.31
5.282
0
0
GO:0016741 transferase activity, transferring one-carbon groups
14none
 
 
after_TSS
31
98
31.6
13.6
2.31
5.187
0
0
GO:0008168 methyltransferase activity
15none
 
yes
at_TSS
31
302
10.2
5.8
1.75
3.302
0.0009
0.0087
GO:0005667
16none
 
 
after_TSS
30
128
23.4
13.6
1.71
3.224
0.0012
0.066
GO:0043037 translation
17none
 
yes
before_TSS
30
301
9.9
5.4
1.83
3.527
0.0004
0.0041
GO:0007399 nervous system development
18none
 
 
at_TSS
25
78
32
10.6
3.02
6.169
0
0
GO:0005764
19none
 
 
after_TSS
23
86
26.7
13.6
1.95
3.533
0.0004
0.03
GO:0006399 tRNA metabolism
20none
 
yes
after_TSS
22
202
10.8
5.5
1.97
3.386
0.0007
0.0865
GO:0016071 mRNA metabolism
21none
 
 
after_TSS
20
74
27
13.6
1.97
3.347
0.0008
0.0747
GO:0042254 ribosome biogenesis and assembly
22none
 
 
after_TSS
19
58
32.7
13.6
2.39
4.234
0
0.0042
GO:0005730
23none
 
yes
at_TSS
19
128
14.8
5.8
2.53
4.351
0
0.0008
GO:0007389 pattern specification
24none
 
 
at_TSS
18
86
20.9
10.6
1.97
3.119
0.0018
0.0301
GO:0008135 translation factor activity, nucleic acid binding
25none
 
yes
after_TSS
18
149
12
5.5
2.19
3.542
0.0003
0.0726
GO:0000398 nuclear mRNA splicing, via spliceosome
26none
 
yes
after_TSS
18
149
12
5.5
2.19
3.542
0.0003
0.0726
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
27none
 
yes
after_TSS
18
149
12
5.5
2.19
3.542
0.0003
0.0726
GO:0000375 RNA splicing, via transesterification reactions
28none
 
 
at_TSS
18
90
20
10.6
1.88
2.903
0.0036
0.0541
GO:0045182 translation regulator activity
29none
 
 
at_TSS
17
68
25
10.6
2.35
3.864
0.0001
0.0204
GO:0005342 organic acid transporter activity
30none
 
 
at_TSS
17
68
25
10.6
2.35
3.864
0.0001
0.0204
GO:0046943 carboxylic acid transporter activity
31none
 
 
after_TSS
17
53
32
13.6
2.34
3.901
0
0.0175
GO:0048037 cofactor binding
32none
 
 
after_TSS
16
53
30.1
13.6
2.2
3.501
0.0004
0.0848
GO:0046483 heterocycle metabolism
33none
 
yes
before_TSS
16
149
10.7
5.4
1.98
2.884
0.0039
0.0684
GO:0009892 negative regulation of metabolism
34none
 
yes
before_TSS
15
132
11.3
5.4
2.09
3.032
0.0024
0.0493
GO:0031324 negative regulation of cellular metabolism
35none
 
yes
before_TSS
15
121
12.3
5.4
2.28
3.406
0.0006
0.016
GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
36none
 
yes
before_TSS
15
137
10.9
5.4
2.02
2.874
0.004
0.0412
GO:0030182 neuron differentiation
37none
 
 
at_TSS
15
58
25.8
10.6
2.43
3.781
0.0001
0.0114
GO:0005730
38none
 
 
after_TSS
14
44
31.8
13.6
2.32
3.504
0.0004
0.0559
GO:0050662 coenzyme binding
39none
 
 
after_TSS
14
31
45.1
13.6
3.29
5.103
0
0.0001
GO:0016072 rRNA metabolism
40none
 
yes
before_TSS
14
115
12.1
5.4
2.24
3.213
0.0013
0.024
GO:0016481 negative regulation of transcription
41none
 
 
after_TSS
13
29
44.8
13.6
3.27
4.883
0
0.0003
GO:0006364 rRNA processing
42none
 
yes
after_TSS
13
86
15.1
5.5
2.74
3.923
0
0.032
GO:0008135 translation factor activity, nucleic acid binding
43none
 
yes
after_TSS
13
90
14.4
5.5
2.62
3.733
0.0001
0.0692
GO:0045182 translation regulator activity
44none
 
 
after_TSS
12
32
37.5
13.6
2.73
3.923
0
0.0106
GO:0008033 tRNA processing
45none
 
yes
before_TSS
11
76
14.4
5.4
2.67
3.496
0.0004
0.0069
GO:0007417 central nervous system development
46none
 
yes
before_TSS
11
63
17.4
5.4
3.22
4.231
0
0.0007
GO:0007420 brain development
47none
 
 
at_TSS
10
31
32.2
10.6
3.04
3.919
0
0.004
GO:0016072 rRNA metabolism
48none
 
yes
at_TSS
10
55
18.1
5.8
3.1
3.9
0
0.0352
GO:0046942 carboxylic acid transport
49none
 
yes
at_TSS
10
55
18.1
5.8
3.1
3.9
0
0.0352
GO:0015849 organic acid transport
50MIT_006SP1
 
 
at_TSS
15
78
19.2
4.3
4.39
6.439
0
0
GO:0005764
51MIT_018SREBP
 
 
at_TSS
10
78
12.8
0.6
20.68
13.774
0
0
GO:0005764
52MIT_174
 
 
before_TSS
10
172
5.8
1.6
3.6
4.409
0
0.0748
GO:0003735 structural constituent of ribosome
53TF_AHR
 
 
after_TSS
22
273
8
3.1
2.53
4.658
0
0.0114
GO:0006396 RNA processing
54TF_ELK
 
 
after_TSS
17
280
6
2.1
2.78
4.508
0
0.0404
GO:0016887 ATPase activity
55TF_ELK
 
 
after_TSS
13
98
13.2
2.1
6.08
7.542
0
0
GO:0008168 methyltransferase activity
56TF_ELK
 
 
after_TSS
13
101
12.8
2.1
5.9
7.385
0
0
GO:0016741 transferase activity, transferring one-carbon groups
57TF_FOXD
 
 
before_TSS
11
61
18
4.6
3.85
4.952
0
0.0317
GO:0016042 lipid catabolism
58TF_GABP
 
 
after_TSS
18
342
5.2
1.4
3.72
6.119
0
0
GO:0016070 RNA metabolism
59TF_HNF3
 
 
before_TSS
11
61
18
5
3.59
4.669
0
0.0654
GO:0016042 lipid catabolism
60TF_MYB
 
 
before_TSS
10
119
8.4
2.1
3.83
4.654
0
0.0468
GO:0007276 gametogenesis
61TF_NFY
 
 
at_TSS
10
121
8.2
1.7
4.6
5.391
0
0.003
GO:0016829 lyase activity
62TF_PAX4
 
 
before_TSS
10
107
9.3
2.3
3.96
4.79
0
0.036
GO:0050790 regulation of enzyme activity
63TF_SREBP1
 
 
at_TSS
12
78
15.3
0.9
15.38
12.81
0
0
GO:0005764