CisView Mouse (mm6, March 2005)

Main Gene Ontology terms for targets of TF_NFKB

No.GO annotation
Total
genes
with GO
Location
Max no. of
genes with
TF_NFKB
TF_NFKB alone
In pair
with
1GO:0007275 development
1378
before_TSS
133
yes
 
2GO:0048513 organ development
852
before_TSS
87
yes
 
3GO:0009653 morphogenesis
811
before_TSS
80
yes
 
4GO:0030528 transcription regulator activity
941
before_TSS
72
 
TF_AHR, TF_HNF4,
5GO:0009887 organ morphogenesis
674
before_TSS
71
yes
 
6GO:0030554 adenyl nucleotide binding
1036
at_TSS
57
 
TF_AP2, TF_AP2A,
7GO:0005524 ATP binding
1011
at_TSS
56
 
TF_AP2, TF_AP2A,
8GO:0030154 cell differentiation
538
before_TSS
54
yes
TF_MAZR,
9GO:0043207 response to external biotic stimulus
237
at_TSS
52
yes
 
10GO:0006468 protein amino acid phosphorylation
476
before_TSS
46
yes
 
11GO:0006796 phosphate metabolism
654
before_TSS
42
 
TF_RFX, MIT_006SP1,
12GO:0006793 phosphorus metabolism
654
before_TSS
42
 
TF_RFX, MIT_006SP1,
13GO:0007049 cell cycle
443
before_TSS
37
 
TF_SP1,
14GO:0007399 nervous system development
301
before_TSS,after_TSS
37
yes
 
15GO:0007155 cell adhesion
395
at_TSS
34
yes
 
16GO:0016568 chromatin modification
78
after_TSS
32
yes
 
17GO:0016310 phosphorylation
549
before_TSS
30
 
TF_RFX,
18GO:0006357 regulation of transcription from RNA polymerase II promoter
191
after_TSS
27
yes
 
19GO:0000074 regulation of progression through cell cycle
246
before_TSS
24
 
TF_SP1,
20GO:0006954 inflammatory response
101
at_TSS
24
yes
 
21GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
91
at_TSS
23
yes
 
22GO:0050795 regulation of behavior
38
before_TSS
23
yes
 
23GO:0040012 regulation of locomotion
37
before_TSS
23
yes
 
24GO:0004674 protein serine/threonine kinase activity
418
at_TSS
22
 
MIT_006SP1,
25GO:0051270 regulation of cell motility
35
before_TSS
22
yes
 
26GO:0005125 cytokine activity
173
at_TSS
22
yes
 
27GO:0008134 transcription factor binding
110
after_TSS
22
yes
 
28GO:0030334 regulation of cell migration
34
before_TSS
21
yes
 
29GO:0009611 response to wounding
180
at_TSS
21
yes
 
30GO:0019955 cytokine binding
53
at_TSS
21
yes
 
31GO:0003712 transcription cofactor activity
94
after_TSS
21
yes
 
32GO:0006928 cell motility
162
before_TSS
19
yes
 
33GO:0040011 locomotion
165
before_TSS
19
yes
 
34GO:0004896 hematopoietin/interferon-class (D200-domain) cytokine receptor activity
51
at_TSS
19
yes
 
35GO:0016477 cell migration
141
before_TSS
17
yes
 
36GO:0006396 RNA processing
273
after_TSS
17
 
TF_MYB,
37GO:0007389 pattern specification
128
before_TSS
16
yes
 
38GO:0006397 mRNA processing
189
after_TSS
14
 
TF_MYB,
39GO:0019965 interleukin binding
29
at_TSS
14
yes
 
40GO:0016071 mRNA metabolism
202
after_TSS
14
 
TF_MYB,
41GO:0004907 interleukin receptor activity
29
at_TSS
14
yes
 
42GO:0016055 Wnt receptor signaling pathway
81
before_TSS
13
yes
 
43GO:0008009 chemokine activity
32
at_TSS
12
yes
 
44GO:0042379 chemokine receptor binding
32
at_TSS
12
yes
 
45GO:0006260 DNA replication
90
at_TSS
12
 
TF_GABP, TF_ELK,
46GO:0001501 skeletal development
87
before_TSS
12
yes
 
47GO:0003713 transcription coactivator activity
52
after_TSS
11
yes
 
48GO:0008380 RNA splicing
154
after_TSS
11
 
TF_MYB,
49GO:0000398 nuclear mRNA splicing, via spliceosome
149
after_TSS
10
 
TF_MYB,
50GO:0007519 myogenesis
34
after_TSS
10
yes
 
51GO:0009451 RNA modification
64
at_TSS
10
 
TF_GABP, TF_ELK,
52GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
149
after_TSS
10
 
TF_MYB,
53GO:0000375 RNA splicing, via transesterification reactions
149
after_TSS
10
 
TF_MYB,

Pairs of TF_NFKB binding sites with other TFBS

No.TFBS
Location
Total GO-s
Main GO annotation
N pairs for
main GO
Total genes
for main GO
1TF_MYB
after_TSS
7
GO:0006396 RNA processing
17
273
2TF_RFX
before_TSS
3
GO:0006796 phosphate metabolism
35
654
3MIT_006SP1
at_TSS,before_TSS
3
GO:0006796 phosphate metabolism
42
654
4TF_GABP
at_TSS
2
GO:0009451 RNA modification
10
64
5TF_AP2A
at_TSS
2
GO:0030554 adenyl nucleotide binding
57
1036
6TF_ELK
at_TSS
2
GO:0006260 DNA replication
12
90
7TF_SP1
before_TSS
2
GO:0007049 cell cycle
37
443
8TF_AP2
at_TSS
2
GO:0030554 adenyl nucleotide binding
57
1036
9TF_MAZR
before_TSS
1
GO:0030154 cell differentiation
46
538
10TF_HNF4
before_TSS
1
GO:0030528 transcription regulator activity
48
941
11TF_AHR
before_TSS
1
GO:0030528 transcription regulator activity
72
941

Details on Gene Ontology terms for targets of TF_NFKB

Total number of genes = 12103
No.In pair
with
Multi-
ple
Conser-
ved
Location
Frequency
in list
U-clusters
in list
Genes with TFBS
in list, %
Genes with TFBS
total, %
Ratio
z
p
FDR
GO annotation
1none
 
yes
before_TSS
133
1378
9.6
6.2
1.55
5.633
0
0
GO:0007275 development
2none
 
yes
before_TSS
87
852
10.2
6.2
1.64
5.027
0
0
GO:0048513 organ development
3none
 
yes
before_TSS
80
811
9.8
6.2
1.58
4.471
0
0
GO:0009653 morphogenesis
4none
 
yes
before_TSS
71
674
10.5
6.2
1.69
4.793
0
0
GO:0009887 organ morphogenesis
5none
 
yes
before_TSS
54
538
10
6.2
1.61
3.768
0.0001
0.003
GO:0030154 cell differentiation
6none
 
 
at_TSS
52
237
21.9
13.8
1.58
3.628
0.0002
0.0047
GO:0043207 response to external biotic stimulus
7none
 
yes
before_TSS
46
476
9.6
6.2
1.55
3.191
0.0014
0.0432
GO:0006468 protein amino acid phosphorylation
8none
 
yes
after_TSS
37
301
12.2
7.9
1.54
2.828
0.0046
0.0519
GO:0007399 nervous system development
9none
 
yes
at_TSS
34
395
8.6
5.3
1.59
2.872
0.004
0.0933
GO:0007155 cell adhesion
10none
 
yes
before_TSS
33
301
10.9
6.2
1.76
3.465
0.0005
0.0047
GO:0007399 nervous system development
11none
 
 
after_TSS
32
78
41
24.9
1.64
3.297
0.0009
0.0447
GO:0016568 chromatin modification
12none
 
yes
after_TSS
27
191
14.1
7.9
1.78
3.192
0.0014
0.0517
GO:0006357 regulation of transcription from RNA polymerase II promoter
13none
 
 
at_TSS
24
101
23.7
13.8
1.71
2.887
0.0038
0.0948
GO:0006954 inflammatory response
14none
 
 
at_TSS
23
91
25.2
13.8
1.82
3.158
0.0015
0.0646
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
15none
 
 
before_TSS
23
38
60.5
27.9
2.16
4.49
0
0.0026
GO:0050795 regulation of behavior
16none
 
 
before_TSS
23
37
62.1
27.9
2.22
4.653
0
0.0011
GO:0040012 regulation of locomotion
17none
 
 
before_TSS
22
35
62.8
27.9
2.25
4.617
0
0.0014
GO:0051270 regulation of cell motility
18none
 
yes
at_TSS
22
173
12.7
5.3
2.35
4.292
0
0.0032
GO:0005125 cytokine activity
19none
 
yes
after_TSS
22
110
20
7.9
2.51
4.699
0
0.0009
GO:0008134 transcription factor binding
20none
 
 
before_TSS
21
34
61.7
27.9
2.21
4.408
0
0.0038
GO:0030334 regulation of cell migration
21none
 
yes
at_TSS
21
180
11.6
5.3
2.16
3.752
0.0001
0.0642
GO:0009611 response to wounding
22none
 
 
at_TSS
21
53
39.6
13.8
2.85
5.435
0
0
GO:0019955 cytokine binding
23none
 
yes
after_TSS
21
94
22.3
7.9
2.81
5.183
0
0
GO:0003712 transcription cofactor activity
24none
 
 
at_TSS
19
51
37.2
13.8
2.68
4.84
0
0.0004
GO:0004896 hematopoietin/interferon-class (D200-domain) cytokine receptor activity
25none
 
yes
before_TSS
19
162
11.7
6.2
1.89
2.933
0.0033
0.0472
GO:0006928 cell motility
26none
 
yes
before_TSS
19
165
11.5
6.2
1.85
2.846
0.0044
0.0578
GO:0040011 locomotion
27none
 
yes
before_TSS
17
141
12
6.2
1.94
2.897
0.0037
0.0811
GO:0016477 cell migration
28none
 
yes
before_TSS
16
128
12.5
6.2
2.01
2.967
0.003
0.0215
GO:0007389 pattern specification
29none
 
 
at_TSS
14
29
48.2
13.8
3.47
5.366
0
0
GO:0019965 interleukin binding
30none
 
 
at_TSS
14
29
48.2
13.8
3.47
5.366
0
0
GO:0004907 interleukin receptor activity
31none
 
yes
before_TSS
13
81
16
6.2
2.58
3.684
0.0002
0.028
GO:0016055 Wnt receptor signaling pathway
32none
 
 
at_TSS
12
32
37.5
13.8
2.7
3.871
0.0001
0.0198
GO:0042379 chemokine receptor binding
33none
 
yes
before_TSS
12
87
13.7
6.2
2.22
2.944
0.0032
0.079
GO:0001501 skeletal development
34none
 
 
at_TSS
12
32
37.5
13.8
2.7
3.871
0.0001
0.0198
GO:0008009 chemokine activity
35none
 
yes
after_TSS
11
52
21.1
7.9
2.66
3.531
0.0004
0.0757
GO:0003713 transcription coactivator activity
36none
 
yes
after_TSS
10
34
29.4
7.9
3.7
4.637
0
0.0012
GO:0007519 myogenesis
37MIT_006SP1
 
 
before_TSS
42
654
6.4
3.4
1.85
4.257
0
0.0895
GO:0006796 phosphate metabolism
38MIT_006SP1
 
 
before_TSS
42
654
6.4
3.4
1.85
4.257
0
0.0895
GO:0006793 phosphorus metabolism
39MIT_006SP1
yes
 
at_TSS
22
418
5.2
2
2.52
4.635
0
0.0308
GO:0004674 protein serine/threonine kinase activity
40TF_AHR
 
 
before_TSS
72
941
7.6
4.8
1.58
4.212
0
0.0331
GO:0030528 transcription regulator activity
41TF_AP2
 
 
at_TSS
57
1036
5.5
3.1
1.75
4.559
0
0.0246
GO:0030554 adenyl nucleotide binding
42TF_AP2
 
 
at_TSS
56
1011
5.5
3.1
1.76
4.569
0
0.0302
GO:0005524 ATP binding
43TF_AP2A
 
 
at_TSS
57
1036
5.5
3.1
1.72
4.408
0
0.045
GO:0030554 adenyl nucleotide binding
44TF_AP2A
 
 
at_TSS
56
1011
5.5
3.1
1.73
4.42
0
0.0328
GO:0005524 ATP binding
45TF_ELK
 
 
at_TSS
12
90
13.3
3.5
3.78
5.07
0
0.001
GO:0006260 DNA replication
46TF_ELK
 
 
at_TSS
10
64
15.6
3.5
4.43
5.268
0
0.0009
GO:0009451 RNA modification
47TF_GABP
 
 
at_TSS
10
64
15.6
2.5
6.13
6.662
0
0
GO:0009451 RNA modification
48TF_GABP
 
 
at_TSS
10
90
11.1
2.5
4.36
5.179
0
0.0006
GO:0006260 DNA replication
49TF_HNF4
 
 
before_TSS
48
941
5.1
2.9
1.74
4.146
0
0.0384
GO:0030528 transcription regulator activity
50TF_MAZR
 
 
before_TSS
46
538
8.5
4
2.1
5.403
0
0.0014
GO:0030154 cell differentiation
51TF_MYB
 
 
after_TSS
17
273
6.2
1.8
3.45
5.561
0
0.0001
GO:0006396 RNA processing
52TF_MYB
 
 
after_TSS
14
202
6.9
1.8
3.84
5.527
0
0.0001
GO:0016071 mRNA metabolism
53TF_MYB
 
 
after_TSS
14
189
7.4
1.8
4.11
5.84
0
0
GO:0006397 mRNA processing
54TF_MYB
 
 
after_TSS
11
154
7.1
1.8
3.96
5.016
0
0.0019
GO:0008380 RNA splicing
55TF_MYB
 
 
after_TSS
10
149
6.7
1.8
3.72
4.534
0
0.0147
GO:0000398 nuclear mRNA splicing, via spliceosome
56TF_MYB
 
 
after_TSS
10
149
6.7
1.8
3.72
4.534
0
0.0147
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
57TF_MYB
 
 
after_TSS
10
149
6.7
1.8
3.72
4.534
0
0.0147
GO:0000375 RNA splicing, via transesterification reactions
58TF_RFX
 
 
before_TSS
35
654
5.3
2.5
2.09
4.665
0
0.0444
GO:0006796 phosphate metabolism
59TF_RFX
 
 
before_TSS
35
654
5.3
2.5
2.09
4.665
0
0.0444
GO:0006793 phosphorus metabolism
60TF_RFX
 
 
before_TSS
30
549
5.4
2.5
2.14
4.426
0
0.0691
GO:0016310 phosphorylation
61TF_SP1
 
 
before_TSS
37
443
8.3
4.1
2.01
4.534
0
0.0113
GO:0007049 cell cycle
62TF_SP1
 
 
before_TSS
24
246
9.7
4.1
2.35
4.467
0
0.0571
GO:0000074 regulation of progression through cell cycle