TFBS = ADD

CisView: Mouse (mm9, Jul 2007)

Transcription factor binding site ADD_CTCFB

Source: Moon H, Filippova G, Loukinov D, Pugacheva E, Chen Q, Smith ST, Munhall A, Grewe B, Bartkuhn M, Arnold R, Burke LJ, Renkawitz-Pohl R, Ohlsson R, Zhou J, Renkawitz R, Lobanenkov V. 2005.CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep. 6:165-70.
TF group: CTCF
Pattern = GCCGCTAGGGGGCGG (core elements are bold) Class: CTCF Allowed mismatch: 0.2
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Position weight matrix:

position A C G T
1 1 2 4 0
2 0 7 0 1
3 1 6 1 0
4 0 1 5 2
5 0 6 1 1
6 0 1 2 5
7 8 0 0 0
8 0 0 8 0
9 1 0 7 0
10 0 0 7 1
11 1 0 7 0
12 0 1 6 1
13 1 6 1 0
14 2 1 4 1
15 0 2 5 0

Genes (trans-elements):

U-cluster Symbol Annotation
U009750 Ctcf CCCTC-binding factor
U197485 Ctcfl CCCTC-binding factor (zinc finger protein)-like

GO terms:
GO:0045786 negative regulation of cell cycle
GO:0006306 DNA methylation
GO:0006349 genetic imprinting
GO:0010216 maintenance of DNA methylation
GO:0008270 zinc ion binding
GO:0009048 dosage compensation, by inactivation of X chromosome
GO:0046872 metal ion binding
GO:0007049 cell cycle

Protein domains:
IPR004243 Minor capsid protein VI
IPR015880 Zinc finger, C2H2-like
IPR002929 Potato leaf roll virus readthrough protein
IPR013859 Protein of unknown function DUF1750, fungi
IPR010627 Peptidase A24A, N-terminal
IPR007625 Herpesvirus UL51 protein
IPR008882 Procyclic acidic repetitive

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

position	A	C	G	T
1	1	2	4	0
2	0	7	0	1
3	1	6	1	0
4	0	1	5	2
5	0	6	1	1
6	0	1	2	5
7	8	0	0	0
8	0	0	8	0
9	1	0	7	0
10	0	0	7	1
11	1	0	7	0
12	0	1	6	1
13	1	6	1	0
14	2	1	4	1
15	0	2	5	0

U-cluster	Symbol	Annotation
U009750	Ctcf	CCCTC-binding factor
U197485	Ctcfl	CCCTC-binding factor (zinc finger protein)-like

Legend