CisView: Mouse (mm9, Jul 2007)
Transcription factor binding site ADD_FOXP3

Source: Schubert LA, Jeffery E, Zhang Y, Ramsdell F, Ziegler SF. 2001.Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem. 276(40):37672-9.
TF group: FOXP3       TFBS class: FH = Fork head       Code: 3.3
Pattern = VAWTRTTKRYTY     Class: FOXP3     Allowed mismatch: 0     Palindrome
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Genes (trans-elements):
U-clusterSymbol
Annotation
U019658Foxp3forkhead box P3

GO terms:
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0032693 negative regulation of interleukin-10 production
GO:0050852 T cell receptor signaling pathway
GO:0002669 positive regulation of T cell anergy
GO:0042803 protein homodimerization activity
GO:0002513 tolerance induction to self antigen
GO:0045066 regulatory T cell differentiation
GO:0043565 sequence-specific DNA binding
GO:0032715 negative regulation of interleukin-6 production
GO:0002851 positive regulation of peripheral T cell tolerance induction
GO:0033092 positive regulation of immature T cell proliferation in the thymus
GO:0001816 cytokine production
GO:0032713 negative regulation of interleukin-4 production
GO:0045077 negative regulation of interferon-gamma biosynthetic process
GO:0003714 transcription corepressor activity
GO:0002637 regulation of immunoglobulin production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0042130 negative regulation of T cell proliferation
GO:0046872 metal ion binding
GO:0035066 positive regulation of histone acetylation
GO:0016564 transcription repressor activity
GO:0016563 transcription activator activity
GO:0002456 T cell mediated immunity
GO:0002677 negative regulation of chronic inflammatory response
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0001782 B cell homeostasis
GO:0003705 RNA polymerase II transcription factor activity, enhancer binding
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0008270 zinc ion binding
GO:0045892 negative regulation of transcription, DNA-dependent
GO:0002666 positive regulation of T cell tolerance induction
GO:0032703 negative regulation of interleukin-2 production
GO:0032714 negative regulation of interleukin-5 production
GO:0016566 specific transcriptional repressor activity
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050728 negative regulation of inflammatory response
GO:0032914 positive regulation of transforming growth factor-beta1 production
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0042110 T cell activation
GO:0035067 negative regulation of histone acetylation
GO:0002262 myeloid cell homeostasis
GO:0002507 tolerance induction
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0032689 negative regulation of interferon-gamma production

Protein domains:
IPR006942 TH1 protein
IPR001766 Fork head transcription factor

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

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