TFBS = ADD

Transcription factor binding site ADD_LRH

Source: Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ. 2005. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol Cell Biol. 25(9):3492-3505.
TF group: SF1 TFBS class: HR = Hormone receptor Code: 2.1.4
Pattern = TCAAGGYYA (core elements are bold) Class: SF1 Allowed mismatch: 0.047
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Position weight matrix:

position A C G T
1 1 5 1 11
2 0 18 0 0
3 18 0 0 0
4 18 0 0 0
5 0 0 18 0
6 0 0 17 1
7 2 7 3 6
8 0 11 0 7
9 10 3 5 0

Genes (trans-elements):

U-cluster Symbol Annotation
U021824 Nr5a2 nuclear receptor subfamily 5, group A, member 2

GO terms:
GO:0004872 receptor activity
GO:0043565 sequence-specific DNA binding
GO:0008206 bile acid metabolic process
GO:0004879 ligand-dependent nuclear receptor activity
GO:0046872 metal ion binding
GO:0008289 lipid binding
GO:0008270 zinc ion binding
GO:0003707 steroid hormone receptor activity
GO:0042632 cholesterol homeostasis

Protein domains:
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR000536 Nuclear hormone receptor, ligand-binding, core

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

U-cluster	Symbol	Annotation
U021824	Nr5a2	nuclear receptor subfamily 5, group A, member 2