CisView: Mouse (mm9, Jul 2007)
Transcription factor binding site ADD_SMAD3A

Source: Stroschein SL, Wang W, Luo K. 1999. Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation. J Biol Chem. 274:9431-41.
TF group: SMAD       TFBS class: SMAD       Code: 4.12.1
Pattern = GTCTAGAC     Class: SMAD     Allowed mismatch: 0     Palindrome
Overlap with other TFBS Open table
GO-annotations for traget genes Open table

Genes (trans-elements):
U-clusterSymbol
Annotation
U029992Smad1MAD homolog 1 (Drosophila)
U030990Smad3MAD homolog 3 (Drosophila)
U038549Smad4MAD homolog 4 (Drosophila)
U141140Smad2MAD homolog 2 (Drosophila)

GO terms:
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0016563 transcription activator activity
GO:0051098 regulation of binding
GO:0007183 SMAD protein complex assembly
GO:0009887 organ morphogenesis
GO:0003690 double-stranded DNA binding
GO:0009952 anterior/posterior pattern formation
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell proliferation
GO:0001707 mesoderm formation
GO:0048340 paraxial mesoderm morphogenesis
GO:0042592 homeostatic process
GO:0001822 kidney development
GO:0009791 post-embryonic development
GO:0045668 negative regulation of osteoblast differentiation
GO:0030324 lung development
GO:0007389 pattern specification process
GO:0030073 insulin secretion
GO:0007184 SMAD protein nuclear translocation
GO:0002076 osteoblast development
GO:0009749 response to glucose stimulus
GO:0016202 regulation of striated muscle development
GO:0048663 neuron fate commitment
GO:0007242 intracellular signaling cascade
GO:0001658 ureteric bud branching
GO:0000165 MAPKKK cascade
GO:0035265 organ growth
GO:0007276 gamete generation
GO:0045165 cell fate commitment
GO:0007507 heart development
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0030901 midbrain development
GO:0045941 positive regulation of transcription
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0030509 BMP signaling pathway
GO:0045669 positive regulation of osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0042110 T cell activation
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0001702 gastrulation with mouth forming second
GO:0031016 pancreas development
GO:0050678 regulation of epithelial cell proliferation
GO:0002051 osteoblast fate commitment
GO:0050776 regulation of immune response
GO:0030902 hindbrain development

Protein domains:
IPR001132 MAD homology 2, Dwarfin-type
IPR003619 MAD homology 1, Dwarfin-type
IPR010820 Protein of unknown function DUF1421
IPR008781 Pneumovirinae attachment membrane glycoprotein G

Frequency distribution in CpG-rich and CpG-poor promoters (per 1Mb)

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