NIA Mouse Gene Index, mm9

6199. U002699
Annotation: itchy, E3 ubiquitin protein ligase     Gene?: Yes     Source: NM_001243712    Symbol:  Itch
Chromosome: chr2   Strand: +    Start: 154955939    End: 155052591
List: Positive strand of chr2 (N=7576)

Genome Browsers: NCBI - UCSC - Ensembl
View Regulatory Regions


Exon structure

Domains
IPR000569 - HECT
IPR008781 - Pneumovirinae attachment membrane glycoprotein G
IPR002951 - Atrophin
IPR001202 - WW/Rsp5/WWP
IPR000008 - C2 calcium-dependent membrane targeting
IPR007797 - AF-4 proto-oncoprotein

GO-Ontologies
GO:0043021 - ribonucleoprotein complex binding
GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006464 - protein modification process
GO:0016881 - acid-amino acid ligase activity
GO:0005737 - cytoplasm
GO:0009615 - response to virus
GO:0005515 - protein binding
GO:0005624 - membrane fraction
GO:0005938 - cell cortex
GO:0070534 - protein K63-linked ubiquitination
GO:0006915 - apoptotic process
GO:0016020 - membrane
GO:0070936 - protein K48-linked ubiquitination
GO:0031410 - cytoplasmic vesicle
GO:0005622 - intracellular
GO:0043066 - negative regulation of apoptotic process
GO:0090085 - regulation of protein deubiquitination
GO:0000209 - protein polyubiquitination
GO:0016567 - protein ubiquitination
GO:0002669 - positive regulation of T cell anergy
GO:0035519 - protein K29-linked ubiquitination
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0045087 - innate immune response
GO:0016874 - ligase activity
GO:0046329 - negative regulation of JNK cascade
GO:0045732 - positive regulation of protein catabolic process
GO:0046642 - negative regulation of alpha-beta T cell proliferation
GO:0000151 - ubiquitin ligase complex
GO:0005886 - plasma membrane
GO:0004842 - ubiquitin-protein ligase activity
GO:0045236 - CXCR chemokine receptor binding
GO:0005634 - nucleus
GO:0050687 - negative regulation of defense response to virus
GO:0032088 - negative regulation of NF-kappaB transcription factor activity