NIA Mouse Gene Index, mm9

2082. U004422
Annotation: toll-like receptor 4     Gene?: Yes     Source: NM_021297    Symbol:  Tlr4
Chromosome: chr4   Strand: +    Start: 66488584    End: 66591318
List: Positive strand of chr4 (N=6286)

Genome Browsers: NCBI - UCSC - Ensembl
View Regulatory Regions


Exon structure

Domains
IPR000157 - Toll-Interleukin receptor
IPR000483 - Cysteine-rich flanking region, C-terminal

GO-Ontologies
GO:0051091 - positive regulation of sequence-specific DNA binding transcription factor activity
GO:0002218 - activation of innate immune response
GO:0032760 - positive regulation of tumor necrosis factor production
GO:0070374 - positive regulation of ERK1 and ERK2 cascade
GO:0071223 - cellular response to lipoteichoic acid
GO:0060729 - intestinal epithelial structure maintenance
GO:0045359 - positive regulation of interferon-beta biosynthetic process
GO:0005515 - protein binding
GO:0050729 - positive regulation of inflammatory response
GO:0032496 - response to lipopolysaccharide
GO:0032722 - positive regulation of chemokine production
GO:0006955 - immune response
GO:0045576 - mast cell activation
GO:0032497 - detection of lipopolysaccharide
GO:0045368 - positive regulation of interleukin-13 biosynthetic process
GO:0016020 - membrane
GO:0032715 - negative regulation of interleukin-6 production
GO:0000187 - activation of MAPK activity
GO:0032757 - positive regulation of interleukin-8 production
GO:0032729 - positive regulation of interferon-gamma production
GO:0042116 - macrophage activation
GO:0042346 - positive regulation of NF-kappaB import into nucleus
GO:0045410 - positive regulation of interleukin-6 biosynthetic process
GO:0005622 - intracellular
GO:0043123 - positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032720 - negative regulation of tumor necrosis factor production
GO:0010572 - positive regulation of platelet activation
GO:0002537 - nitric oxide production involved in inflammatory response
GO:0032874 - positive regulation of stress-activated MAPK cascade
GO:0009617 - response to bacterium
GO:0005887 - integral to plasma membrane
GO:0002224 - toll-like receptor signaling pathway
GO:0051770 - positive regulation of nitric-oxide synthase biosynthetic process
GO:0032700 - negative regulation of interleukin-17 production
GO:0043388 - positive regulation of DNA binding
GO:0002282 - microglial cell activation involved in immune response
GO:0007250 - activation of NF-kappaB-inducing kinase activity
GO:0032732 - positive regulation of interleukin-1 production
GO:0070430 - positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0050727 - regulation of inflammatory response
GO:0009897 - external side of plasma membrane
GO:0005886 - plasma membrane
GO:0045416 - positive regulation of interleukin-8 biosynthetic process
GO:0045471 - response to ethanol
GO:0032609 - interferon-gamma production
GO:0032733 - positive regulation of interleukin-10 production
GO:0045348 - positive regulation of MHC class II biosynthetic process
GO:0004872 - receptor activity
GO:0006979 - response to oxidative stress
GO:0032689 - negative regulation of interferon-gamma production
GO:0045084 - positive regulation of interleukin-12 biosynthetic process
GO:0042742 - defense response to bacterium
GO:0071222 - cellular response to lipopolysaccharide
GO:0007165 - signal transduction
GO:0001875 - lipopolysaccharide receptor activity
GO:0045429 - positive regulation of nitric oxide biosynthetic process
GO:0005737 - cytoplasm
GO:0043548 - phosphatidylinositol 3-kinase binding
GO:0051092 - positive regulation of NF-kappaB transcription factor activity
GO:0032727 - positive regulation of interferon-alpha production
GO:0032728 - positive regulation of interferon-beta production
GO:0030890 - positive regulation of B cell proliferation
GO:0016021 - integral to membrane
GO:0032707 - negative regulation of interleukin-23 production
GO:0046696 - lipopolysaccharide receptor complex
GO:0045121 - membrane raft
GO:0001530 - lipopolysaccharide binding
GO:0070542 - response to fatty acid
GO:0007252 - I-kappaB phosphorylation
GO:0052033 - pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0060907 - positive regulation of macrophage cytokine production
GO:0070373 - negative regulation of ERK1 and ERK2 cascade
GO:0045362 - positive regulation of interleukin-1 biosynthetic process
GO:0032735 - positive regulation of interleukin-12 production
GO:0046330 - positive regulation of JNK cascade
GO:0050829 - defense response to Gram-negative bacterium
GO:0006954 - inflammatory response
GO:0009986 - cell surface
GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation
GO:0045087 - innate immune response
GO:0002758 - innate immune response-activating signal transduction
GO:0048471 - perinuclear region of cytoplasm
GO:0031663 - lipopolysaccharide-mediated signaling pathway
GO:0051930 - regulation of sensory perception of pain
GO:0004888 - transmembrane signaling receptor activity
GO:0032755 - positive regulation of interleukin-6 production
GO:0042535 - positive regulation of tumor necrosis factor biosynthetic process
GO:0050671 - positive regulation of lymphocyte proliferation
GO:0070434 - positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0043065 - positive regulation of apoptotic process
GO:0045944 - positive regulation of transcription from RNA polymerase II promoter