NIA Mouse Gene Index, mm9

2166. U012684
Annotation: NLR family, pyrin domain containing 3     Gene?: Yes     Source: NM_145827    Symbol:  Nlrp3
Chromosome: chr11   Strand: +    Start: 59355086    End: 59380458
List: Positive strand of chr11 (N=6082)

Genome Browsers: NCBI - UCSC - Ensembl
View Regulatory Regions


Exon structure

Domains
IPR003590 - Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004957 - Spumavirus gag protein
IPR003593 - AAA+ ATPase, core
IPR004020 - Pyrin
IPR007111 - NACHT nucleoside triphosphatase

GO-Ontologies
GO:0043280 - positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 - inflammatory response
GO:0005737 - cytoplasm
GO:0050718 - positive regulation of interleukin-1 beta secretion
GO:0005524 - ATP binding
GO:0032621 - interleukin-18 production
GO:0042347 - negative regulation of NF-kappaB import into nucleus
GO:0050701 - interleukin-1 secretion
GO:0051607 - defense response to virus
GO:0000166 - nucleotide binding
GO:0006915 - apoptotic process
GO:0032088 - negative regulation of NF-kappaB transcription factor activity
GO:0006919 - activation of caspase activity