NIA Mouse Gene Index, mm9

3015. U014175
Annotation: presenilin 1     Gene?: Yes     Source: NM_008943    Symbol:  Psen1
Chromosome: chr12   Strand: +    Start: 85029101    End: 85076149
List: Positive strand of chr12 (N=4634)

Genome Browsers: NCBI - UCSC - Ensembl
View Regulatory Regions


Exon structure

Domains
IPR006639 - Peptidase A22, presenilin signal peptide
IPR001108 - Peptidase A22A, presenilin
IPR002656 - Acyltransferase 3

GO-Ontologies
GO:0007507 - heart development
GO:0050673 - epithelial cell proliferation
GO:0031594 - neuromuscular junction
GO:0007176 - regulation of epidermal growth factor-activated receptor activity
GO:0005515 - protein binding
GO:0005624 - membrane fraction
GO:0006915 - apoptotic process
GO:2000059 - negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0016020 - membrane
GO:0005790 - smooth endoplasmic reticulum
GO:0045860 - positive regulation of protein kinase activity
GO:0006874 - cellular calcium ion homeostasis
GO:0006914 - autophagy
GO:0050435 - beta-amyloid metabolic process
GO:0016324 - apical plasma membrane
GO:0043406 - positive regulation of MAP kinase activity
GO:0005622 - intracellular
GO:0050771 - negative regulation of axonogenesis
GO:0031965 - nuclear membrane
GO:0009791 - post-embryonic development
GO:0030165 - PDZ domain binding
GO:0043524 - negative regulation of neuron apoptosis
GO:0035282 - segmentation
GO:0030326 - embryonic limb morphogenesis
GO:0007220 - Notch receptor processing
GO:0044267 - cellular protein metabolic process
GO:0002573 - myeloid leukocyte differentiation
GO:0042325 - regulation of phosphorylation
GO:0006979 - response to oxidative stress
GO:0004175 - endopeptidase activity
GO:0006508 - proteolysis
GO:0001568 - blood vessel development
GO:0005262 - calcium channel activity
GO:0060075 - regulation of resting membrane potential
GO:0001933 - negative regulation of protein phosphorylation
GO:0005938 - cell cortex
GO:0048538 - thymus development
GO:0040011 - locomotion
GO:0005794 - Golgi apparatus
GO:0051563 - smooth endoplasmic reticulum calcium ion homeostasis
GO:0016021 - integral to membrane
GO:0043085 - positive regulation of catalytic activity
GO:0002244 - hemopoietic progenitor cell differentiation
GO:0051604 - protein maturation
GO:0000776 - kinetochore
GO:0007219 - Notch signaling pathway
GO:0002286 - T cell activation involved in immune response
GO:0005743 - mitochondrial inner membrane
GO:0021795 - cerebral cortex cell migration
GO:0021904 - dorsal/ventral neural tube patterning
GO:0030426 - growth cone
GO:0007420 - brain development
GO:0001708 - cell fate specification
GO:0043198 - dendritic shaft
GO:0006916 - anti-apoptosis
GO:0009986 - cell surface
GO:0030425 - dendrite
GO:0035253 - ciliary rootlet
GO:0043227 - membrane-bounded organelle
GO:0000122 - negative regulation of transcription from RNA polymerase II promoter
GO:0004190 - aspartic-type endopeptidase activity
GO:0050820 - positive regulation of coagulation
GO:0050852 - T cell receptor signaling pathway
GO:0043065 - positive regulation of apoptotic process
GO:0051966 - regulation of synaptic transmission, glutamatergic
GO:0070588 - calcium ion transmembrane transport
GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0006974 - response to DNA damage stimulus
GO:0005813 - centrosome
GO:0030018 - Z disc
GO:0006469 - negative regulation of protein kinase activity
GO:0030182 - neuron differentiation
GO:0007155 - cell adhesion
GO:0001947 - heart looping
GO:0048705 - skeletal system morphogenesis
GO:0070765 - gamma-secretase complex
GO:0042987 - amyloid precursor protein catabolic process
GO:0051402 - neuron apoptosis
GO:0015813 - L-glutamate transport
GO:0031410 - cytoplasmic vesicle
GO:0007613 - memory
GO:0005640 - nuclear outer membrane
GO:0016787 - hydrolase activity
GO:0007611 - learning or memory
GO:0043589 - skin morphogenesis
GO:0005887 - integral to plasma membrane
GO:0030900 - forebrain development
GO:0048167 - regulation of synaptic plasticity
GO:0001764 - neuron migration
GO:0005886 - plasma membrane
GO:0048666 - neuron development
GO:0001934 - positive regulation of protein phosphorylation
GO:0019717 - synaptosome
GO:0043234 - protein complex
GO:0045296 - cadherin binding
GO:0015871 - choline transport
GO:0005791 - rough endoplasmic reticulum
GO:0043393 - regulation of protein binding
GO:0000045 - autophagic vacuole assembly
GO:0001756 - somitogenesis
GO:0043025 - neuronal cell body
GO:0048854 - brain morphogenesis
GO:0005765 - lysosomal membrane
GO:0045121 - membrane raft
GO:0007175 - negative regulation of epidermal growth factor-activated receptor activity
GO:0016485 - protein processing
GO:0042640 - anagen
GO:0021987 - cerebral cortex development
GO:0009790 - embryo development
GO:0006509 - membrane protein ectodomain proteolysis
GO:0008013 - beta-catenin binding
GO:0000186 - activation of MAPKK activity
GO:0001921 - positive regulation of receptor recycling
GO:0051444 - negative regulation of ubiquitin-protein ligase activity
GO:0006486 - protein glycosylation
GO:0048471 - perinuclear region of cytoplasm
GO:0022008 - neurogenesis
GO:0021870 - Cajal-Retzius cell differentiation
GO:0032469 - endoplasmic reticulum calcium ion homeostasis
GO:0016337 - cell-cell adhesion
GO:0006839 - mitochondrial transport
GO:0016080 - synaptic vesicle targeting
GO:0005783 - endoplasmic reticulum
GO:0035556 - intracellular signal transduction
GO:0015031 - protein transport
GO:0006816 - calcium ion transport
GO:0030424 - axon
GO:0005739 - mitochondrion
GO:0005634 - nucleus
GO:0008233 - peptidase activity