NIA Mouse Gene Index, mm9

1698. U037744
Annotation: tumor necrosis factor     Gene?: Yes     Source: NM_013693    Symbol:  Tnf
Chromosome: chr17   Strand: -    Start: 35336311    End: 35338952
List: Negative strand of chr17 (N=3916)

Genome Browsers: NCBI - UCSC - Ensembl
View Regulatory Regions


Exon structure

Domains
IPR006052 - Tumor Necrosis Factor

GO-Ontologies
GO:0051091 - positive regulation of sequence-specific DNA binding transcription factor activity
GO:0030141 - secretory granule
GO:0034116 - positive regulation of heterotypic cell-cell adhesion
GO:0002439 - chronic inflammatory response to antigenic stimulus
GO:0046325 - negative regulation of glucose import
GO:0007254 - JNK cascade
GO:0000185 - activation of MAPKKK activity
GO:0050708 - regulation of protein secretion
GO:0005515 - protein binding
GO:0032722 - positive regulation of chemokine production
GO:0042127 - regulation of cell proliferation
GO:0006915 - apoptotic process
GO:0006919 - activation of caspase activity
GO:0005576 - extracellular region
GO:0050830 - defense response to Gram-positive bacterium
GO:0006955 - immune response
GO:0045893 - positive regulation of transcription, DNA-dependent
GO:0045892 - negative regulation of transcription, DNA-dependent
GO:0005615 - extracellular space
GO:0005164 - tumor necrosis factor receptor binding
GO:0050995 - negative regulation of lipid catabolic process
GO:0043243 - positive regulation of protein complex disassembly
GO:0050806 - positive regulation of synaptic transmission
GO:0070265 - necrotic cell death
GO:0016020 - membrane
GO:0032715 - negative regulation of interleukin-6 production
GO:0002740 - negative regulation of cytokine secretion involved in immune response
GO:0000187 - activation of MAPK activity
GO:0032729 - positive regulation of interferon-gamma production
GO:0050796 - regulation of insulin secretion
GO:0042346 - positive regulation of NF-kappaB import into nucleus
GO:0008624 - induction of apoptosis by extracellular signals
GO:0032800 - receptor biosynthetic process
GO:0051384 - response to glucocorticoid stimulus
GO:0043406 - positive regulation of MAP kinase activity
GO:0045071 - negative regulation of viral genome replication
GO:0008283 - cell proliferation
GO:0043123 - positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0005622 - intracellular
GO:0045123 - cellular extravasation
GO:0005887 - integral to plasma membrane
GO:0045672 - positive regulation of osteoclast differentiation
GO:0006952 - defense response
GO:0060693 - regulation of branching involved in salivary gland morphogenesis
GO:0008625 - induction of apoptosis via death domain receptors
GO:0051533 - positive regulation of NFAT protein import into nucleus
GO:0043122 - regulation of I-kappaB kinase/NF-kappaB cascade
GO:0055037 - recycling endosome
GO:0071316 - cellular response to nicotine
GO:0051222 - positive regulation of protein transport
GO:0009897 - external side of plasma membrane
GO:0045670 - regulation of osteoclast differentiation
GO:0006006 - glucose metabolic process
GO:0008284 - positive regulation of cell proliferation
GO:0060557 - positive regulation of vitamin D biosynthetic process
GO:0051023 - regulation of immunoglobulin secretion
GO:0005886 - plasma membrane
GO:0045080 - positive regulation of chemokine biosynthetic process
GO:0061048 - negative regulation of branching involved in lung morphogenesis
GO:0006917 - induction of apoptosis
GO:0001934 - positive regulation of protein phosphorylation
GO:0042742 - defense response to bacterium
GO:0007165 - signal transduction
GO:0030198 - extracellular matrix organization
GO:0045429 - positive regulation of nitric oxide biosynthetic process
GO:0044130 - negative regulation of growth of symbiont in host
GO:0005125 - cytokine activity
GO:0071803 - positive regulation of podosome assembly
GO:0060664 - epithelial cell proliferation involved in salivary gland morphogenesis
GO:0009615 - response to virus
GO:0051092 - positive regulation of NF-kappaB transcription factor activity
GO:0048661 - positive regulation of smooth muscle cell proliferation
GO:0044212 - transcription regulatory region DNA binding
GO:0051798 - positive regulation of hair follicle development
GO:0002876 - positive regulation of chronic inflammatory response to antigenic stimulus
GO:0016021 - integral to membrane
GO:0042802 - identical protein binding
GO:0031334 - positive regulation of protein complex assembly
GO:0019722 - calcium-mediated signaling
GO:0045121 - membrane raft
GO:0060559 - positive regulation of calcidiol 1-monooxygenase activity
GO:0001775 - cell activation
GO:0001932 - regulation of protein phosphorylation
GO:0033138 - positive regulation of peptidyl-serine phosphorylation
GO:0006927 - transformed cell apoptosis
GO:0000060 - protein import into nucleus, translocation
GO:0071230 - cellular response to amino acid stimulus
GO:0002925 - positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0050715 - positive regulation of cytokine secretion
GO:0045994 - positive regulation of translational initiation by iron
GO:0051897 - positive regulation of protein kinase B signaling cascade
GO:0043525 - positive regulation of neuron apoptosis
GO:0043066 - negative regulation of apoptotic process
GO:0046330 - positive regulation of JNK cascade
GO:0009887 - organ morphogenesis
GO:0006954 - inflammatory response
GO:0006916 - anti-apoptosis
GO:0009986 - cell surface
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0006959 - humoral immune response
GO:0001891 - phagocytic cup
GO:0032755 - positive regulation of interleukin-6 production
GO:0050901 - leukocyte tethering or rolling
GO:0007275 - multicellular organismal development
GO:0031622 - positive regulation of fever generation
GO:0001819 - positive regulation of cytokine production
GO:0045840 - positive regulation of mitosis
GO:0060555 - induction of necroptosis by extracellular signals
GO:0000122 - negative regulation of transcription from RNA polymerase II promoter
GO:0008285 - negative regulation of cell proliferation
GO:0002037 - negative regulation of L-glutamate transport
GO:0002020 - protease binding
GO:0030316 - osteoclast differentiation
GO:0030730 - sequestering of triglyceride
GO:0051044 - positive regulation of membrane protein ectodomain proteolysis
GO:0050900 - leukocyte migration
GO:0045944 - positive regulation of transcription from RNA polymerase II promoter