NIA Mouse Gene Index, mm9

2800. U040711
Annotation: nucleotide-binding oligomerization domain containing 2     Gene?: Yes     Source: NM_145857    Symbol:  Nod2
Chromosome: chr8   Strand: +    Start: 91171213    End: 91212373
List: Positive strand of chr8 (N=4546)

Genome Browsers: NCBI - UCSC - Ensembl
View Regulatory Regions


Exon structure

Domains
IPR003590 - Leucine-rich repeat, ribonuclease inhibitor subtype
IPR011029 - DEATH-like
IPR001611 - Leucine-rich repeat
IPR007091 - Leucine-rich repeat, ribonuclease inhibitor type
IPR007111 - NACHT nucleoside triphosphatase
IPR001315 - Caspase Recruitment
IPR001130 - TatD-related deoxyribonuclease

GO-Ontologies
GO:0043330 - response to exogenous dsRNA
GO:0032760 - positive regulation of tumor necrosis factor production
GO:0006965 - positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0002381 - immunoglobulin production during immune response
GO:0002253 - activation of immune response
GO:0005737 - cytoplasm
GO:0005515 - protein binding
GO:0005524 - ATP binding
GO:0032496 - response to lipopolysaccharide
GO:0000166 - nucleotide binding
GO:0051259 - protein oligomerization
GO:0050830 - defense response to Gram-positive bacterium
GO:0045089 - positive regulation of innate immune response
GO:0051092 - activation of NF-kappaB transcription factor
GO:0002227 - innate immune response in mucosa
GO:0032494 - response to peptidoglycan
GO:0034136 - negative regulation of toll-like receptor 2 signaling pathway
GO:0002925 - positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0032495 - response to muramyl dipeptide
GO:0005622 - intracellular
GO:0032735 - positive regulation of interleukin-12 production
GO:0032088 - inhibition of NF-kappaB transcription factor
GO:0046330 - positive regulation of JNK cascade
GO:0032874 - positive regulation of stress-activated MAPK cascade
GO:0006954 - inflammatory response
GO:0002224 - toll-like receptor signaling pathway
GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation
GO:0032701 - negative regulation of interleukin-18 production
GO:0032755 - positive regulation of interleukin-6 production
GO:0032695 - negative regulation of interleukin-12 production
GO:0042981 - regulation of apoptosis
GO:0043410 - positive regulation of MAPKKK cascade
GO:0032689 - negative regulation of interferon-gamma production