NIA Mouse Gene Index, mm9

2914. U040711
Annotation: nucleotide-binding oligomerization domain containing 2     Gene?: Yes     Source: NM_145857    Symbol:  Nod2
Chromosome: chr8   Strand: +    Start: 91171213    End: 91212373
List: Positive strand of chr8 (N=4730)

Genome Browsers: NCBI - UCSC - Ensembl
View Regulatory Regions


Exon structure

Domains
IPR004934 - Tropomodulin
IPR003590 - Leucine-rich repeat, ribonuclease inhibitor subtype
IPR003593 - AAA+ ATPase, core
IPR007111 - NACHT nucleoside triphosphatase
IPR001315 - Caspase Recruitment

GO-Ontologies
GO:0060585 - positive regulation of prostaglandin-endoperoxide synthase activity
GO:0043330 - response to exogenous dsRNA
GO:0002381 - immunoglobulin production involved in immunoglobulin mediated immune response
GO:0032760 - positive regulation of tumor necrosis factor production
GO:0050679 - positive regulation of epithelial cell proliferation
GO:0070374 - positive regulation of ERK1 and ERK2 cascade
GO:0006965 - positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0045747 - positive regulation of Notch signaling pathway
GO:0002732 - positive regulation of dendritic cell cytokine production
GO:0005829 - cytosol
GO:2000110 - negative regulation of macrophage apoptosis
GO:0032498 - detection of muramyl dipeptide
GO:0005515 - protein binding
GO:0032496 - response to lipopolysaccharide
GO:0000166 - nucleotide binding
GO:0051259 - protein oligomerization
GO:0050830 - defense response to Gram-positive bacterium
GO:0045089 - positive regulation of innate immune response
GO:0032494 - response to peptidoglycan
GO:0002367 - cytokine production involved in immune response
GO:0032720 - negative regulation of tumor necrosis factor production
GO:0005622 - intracellular
GO:0043123 - positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043552 - positive regulation of phosphatidylinositol 3-kinase activity
GO:0071608 - macrophage inflammatory protein-1 alpha production
GO:0032874 - positive regulation of stress-activated MAPK cascade
GO:0002830 - positive regulation of type 2 immune response
GO:0032740 - positive regulation of interleukin-17 production
GO:0051770 - positive regulation of nitric-oxide synthase biosynthetic process
GO:0050718 - positive regulation of interleukin-1 beta secretion
GO:0002282 - microglial cell activation involved in immune response
GO:0006952 - defense response
GO:0032731 - positive regulation of interleukin-1 beta production
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0008284 - positive regulation of cell proliferation
GO:0005886 - plasma membrane
GO:0032733 - positive regulation of interleukin-10 production
GO:0035419 - activation of MAPK activity involved in innate immune response
GO:0032689 - negative regulation of interferon-gamma production
GO:0050871 - positive regulation of B cell activation
GO:0042742 - defense response to bacterium
GO:0007165 - signal transduction
GO:0044130 - negative regulation of growth of symbiont in host
GO:0002253 - activation of immune response
GO:0005737 - cytoplasm
GO:0051092 - positive regulation of NF-kappaB transcription factor activity
GO:0071224 - cellular response to peptidoglycan
GO:0090022 - regulation of neutrophil chemotaxis
GO:0051353 - positive regulation of oxidoreductase activity
GO:0005524 - ATP binding
GO:0009595 - detection of biotic stimulus
GO:0070431 - nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031982 - vesicle
GO:0002227 - innate immune response in mucosa
GO:0002606 - positive regulation of dendritic cell antigen processing and presentation
GO:0052033 - pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0034136 - negative regulation of toll-like receptor 2 signaling pathway
GO:0002925 - positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0050766 - positive regulation of phagocytosis
GO:0032495 - response to muramyl dipeptide
GO:0032735 - positive regulation of interleukin-12 production
GO:0046330 - positive regulation of JNK cascade
GO:0006954 - inflammatory response
GO:0009986 - cell surface
GO:0042834 - peptidoglycan binding
GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation
GO:0032701 - negative regulation of interleukin-18 production
GO:0050700 - CARD domain binding
GO:0016888 - endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0032703 - negative regulation of interleukin-2 production
GO:0032500 - muramyl dipeptide binding
GO:0032755 - positive regulation of interleukin-6 production
GO:0019899 - enzyme binding
GO:0031398 - positive regulation of protein ubiquitination
GO:2000363 - positive regulation of prostaglandin-E synthase activity
GO:0032695 - negative regulation of interleukin-12 production
GO:0035556 - intracellular signal transduction
GO:0042981 - regulation of apoptotic process
GO:0002710 - negative regulation of T cell mediated immunity
GO:0016045 - detection of bacterium
GO:0019901 - protein kinase binding
GO:0043410 - positive regulation of MAPKKK cascade
GO:0032088 - negative regulation of NF-kappaB transcription factor activity