NIA Mouse Gene Index, mm9

1952. U089318
Annotation: sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)     Gene?: Yes     Source: NM_019812    Symbol:  Sirt1
Chromosome: chr10   Strand: -    Start: 62781752    End: 62844452
List: Negative strand of chr10 (N=4396)

Genome Browsers: NCBI - UCSC - Ensembl
View Regulatory Regions


Exon structure

Domains
IPR010901 - Merozoite surface 1, C-terminal
IPR003000 - Silent information regulator protein Sir2

GO-Ontologies
GO:0071456 - cellular response to hypoxia
GO:0070301 - cellular response to hydrogen peroxide
GO:0050872 - white fat cell differentiation
GO:0005637 - nuclear inner membrane
GO:0006974 - response to DNA damage stimulus
GO:2000757 - negative regulation of peptidyl-lysine acetylation
GO:0007517 - muscle organ development
GO:0019904 - protein domain specific binding
GO:0018394 - peptidyl-lysine acetylation
GO:0000720 - pyrimidine dimer repair by nucleotide-excision repair
GO:2000655 - negative regulation of cellular response to testosterone stimulus
GO:0005515 - protein binding
GO:0042127 - regulation of cell proliferation
GO:0008022 - protein C-terminus binding
GO:0007283 - spermatogenesis
GO:0006915 - apoptotic process
GO:0034983 - peptidyl-lysine deacetylation
GO:0005730 - nucleolus
GO:0005654 - nucleoplasm
GO:0005677 - chromatin silencing complex
GO:0045892 - negative regulation of transcription, DNA-dependent
GO:0042393 - histone binding
GO:0033158 - regulation of protein import into nucleus, translocation
GO:0001525 - angiogenesis
GO:0033553 - rDNA heterochromatin
GO:0045768 - positive regulation of anti-apoptosis
GO:0034339 - regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
GO:0071356 - cellular response to tumor necrosis factor
GO:0016575 - histone deacetylation
GO:0060766 - negative regulation of androgen receptor signaling pathway
GO:0006355 - regulation of transcription, DNA-dependent
GO:0003714 - transcription corepressor activity
GO:0006343 - establishment of chromatin silencing
GO:0016787 - hydrolase activity
GO:0030308 - negative regulation of cell growth
GO:0005719 - nuclear euchromatin
GO:0034979 - NAD-dependent protein deacetylase activity
GO:0042771 - DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0016567 - protein ubiquitination
GO:0006364 - rRNA processing
GO:0051019 - mitogen-activated protein kinase binding
GO:0000183 - chromatin silencing at rDNA
GO:0043161 - proteasomal ubiquitin-dependent protein catabolic process
GO:0033558 - protein deacetylase activity
GO:0008284 - positive regulation of cell proliferation
GO:0009267 - cellular response to starvation
GO:0006642 - triglyceride mobilization
GO:0017136 - NAD-dependent histone deacetylase activity
GO:0043398 - HLH domain binding
GO:0001542 - ovulation from ovarian follicle
GO:0005635 - nuclear envelope
GO:0006476 - protein deacetylation
GO:0006979 - response to oxidative stress
GO:0045739 - positive regulation of DNA repair
GO:0016605 - PML body
GO:0051097 - negative regulation of helicase activity
GO:0005720 - nuclear heterochromatin
GO:0042326 - negative regulation of phosphorylation
GO:0045599 - negative regulation of fat cell differentiation
GO:0046969 - NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0005737 - cytoplasm
GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity
GO:0016239 - positive regulation of macroautophagy
GO:0019213 - deacetylase activity
GO:0042802 - identical protein binding
GO:0004407 - histone deacetylase activity
GO:0070932 - histone H3 deacetylation
GO:0043518 - negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0006351 - transcription, DNA-dependent
GO:0006344 - maintenance of chromatin silencing
GO:0031937 - positive regulation of chromatin silencing
GO:0000790 - nuclear chromatin
GO:0007346 - regulation of mitotic cell cycle
GO:0032071 - regulation of endodeoxyribonuclease activity
GO:0080134 - regulation of response to stress
GO:0051898 - negative regulation of protein kinase B signaling cascade
GO:0043280 - positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043066 - negative regulation of apoptotic process
GO:0046872 - metal ion binding
GO:0030154 - cell differentiation
GO:0002039 - p53 binding
GO:0008270 - zinc ion binding
GO:0019899 - enzyme binding
GO:0007275 - multicellular organismal development
GO:0043425 - bHLH transcription factor binding
GO:0000122 - negative regulation of transcription from RNA polymerase II promoter
GO:0042981 - regulation of apoptotic process
GO:0005634 - nucleus
GO:0070403 - NAD+ binding
GO:0043065 - positive regulation of apoptotic process
GO:0045944 - positive regulation of transcription from RNA polymerase II promoter
GO:0032088 - negative regulation of NF-kappaB transcription factor activity