Database of mRNA degradation rates in mouse ES cells
|1. mRNA degradation rates measured for 19,977 genes with a time course of microarrays
|2. Unstable mRNA are enriched in transcription factors, signal transduction, and cell cycle genes
|3. Stable mRNA are enriched in structural genes and genes associated with metabolism
|4. Exon junctions strongly increase mRNA stability
|5. ARE and PUF in 3'UTR and CG elements in 5'UTR negatively affected mRNA stability
|6. mRNA stability changed with ES cell differentiation|
Sharova LV, Sharov AA, Nedorezov T, Piao Y, Shaik N, Ko MS. 2009.
Database for mRNA half-life of 19,977 genes obtained by DNA microarray analysis of pluripotent and
differentiating mouse embryonic stem cells. DNA Res. 2009, 16(1): 45-58. Epub 2008 Nov 11.
Microarray Data: NIA Array Analysis and
Gene Expression Omnibus (GEO)
Note: Use the left-side menu to see Methods, main results, and download Supplementary Tables
Please report any problems to webmaster